The article presents and evaluates various approaches to the development of the innovative infrastructure of the region in the era of digitalization, examines the essence of educational innovations, the socio-pedagogical expediency of innovative changes in higher education, and didactic aspects of innovatization considering the digital education principles. The emphasis is placed on an insufficiently studied aspect: the development of a didactic base to prepare human resources for the regional economy development. On the example of TyumSU, the meaningful interaction between educational units of universities and enterprises of the region, the interrelation of innovative, scientific, educational, and scientific-methodological aspects that allow implementing the tasks of the Tyumen region within the framework of socio-economic policy, foreign economic and international interaction of the region with the external environment, including with the EAEU countries, is shown. The article presents an interactive dictionary of the customs sphere as a specific tool for preparing a university graduate to effectively solve practical problems in professional activity, a means of systematizing knowledge in customs. The use of modern technologies to create a digital product that meets the needs of cooperation at the interregional and interstate level is considered.