Competitors versus Collaborators: Micronutrient Processing by Pathogenic and Commensal Human-Associated Gut Bacteria

Celis, Arianna I.; Relman, David A.

doi:10.1016/j.molcel.2020.03.032

Cited by 33 publications

(29 citation statements)

References 44 publications

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“…Any Zn or Fe not absorbed in the small intestine of the healthy human reaches the colon and is available to colonocytes and/or commensal bacteria. Commensal bacteria probably increase the bioavailability of Zn and Fe and provide them to the host [132]. Under conditions of inflammation, pathogens outcompete commensal bacteria for these metals, thereby reducing Fe and Zn levels [132].…”

Section: Association Between Zinc and Gut Microbiotamentioning

confidence: 99%

“…Commensal bacteria probably increase the bioavailability of Zn and Fe and provide them to the host [132]. Under conditions of inflammation, pathogens outcompete commensal bacteria for these metals, thereby reducing Fe and Zn levels [132]. The consumption of Acacia, a prebiotic fiber, has been associated with a higher presence of Lactobacillus and Bifidobacterium spp in the gut and higher Zn concentrations in the femur of Wistar rats [26].…”

Section: Association Between Zinc and Gut Microbiotamentioning

confidence: 99%

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Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Bielik

Kolísek

2021

IJMS

100

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Adequate amounts of a wide range of micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient to meet these micronutrient requirements. Mineral deficiency does not seem to be the result of a physically active life or of athletic training but is more likely to arise from disturbances in the quality and quantity of ingested food. The lack of some minerals in the body appears to be symbolic of the modern era reflecting either the excessive intake of empty calories or a negative energy balance from drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary micronutrient availability and microbial composition in the gut. However, the influence of human gut microbiota on the bioaccessibility and bioavailability of trace elements in human food has rarely been studied. Bacteria play a role by effecting mineral bioavailability and bioaccessibility, which are further increased through the fermentation of cereals and the soaking and germination of crops. Moreover, probiotics have a positive effect on iron, calcium, selenium, and zinc in relation to gut microbiome composition and metabolism. The current literature reveals the beneficial effects of bacteria on mineral bioaccessibility and bioavailability in supporting both the human gut microbiome and overall health. This review focuses on interactions between the gut microbiota and several minerals in sport nutrition, as related to a physically active lifestyle.

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Section: Association Between Zinc and Gut Microbiotamentioning

confidence: 99%

Section: Association Between Zinc and Gut Microbiotamentioning

confidence: 99%

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Bielik

Kolísek

2021

IJMS

100

View full text Add to dashboard Cite

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“…Conversely, predictable gene loss will occur in taxa with lesser relative production efficiencies, and they will become the ''consumers'' of that micronutrient. The driving force is that cooperative production of essential nutrients is energetically favorable over individualistic production (Celis and Relman, 2020). Thus, to form the leanest manufacturing networks possible, it is apparent that microorganisms must extensively share their resources in a communal pool within the extracellular space in order to optimize overall biosynthesis costs at the community level.…”

Section: Redefining Dysbiosismentioning

confidence: 99%

“…Notably, many of the shared resources found abundantly within the human gut pantryome represent well-described bioenergetic molecules (e.g., amino acids, vitamin B cofactors, hemes, quinones) with fundamental roles in basic cellular metabolism. While their ubiquity and established properties may have caused them to be overlooked in the past, mounting evidence suggests that they can exert pleiotropic extracellular effects and that their co-production in microbial communities supports optimal adaptation (Celis and Relman, 2020;Franco-Obrego ´n and Gilbert, 2017;Fritts et al, 2021). For example, they may function as critical mediators in the orchestration of a communally driven interspecies electron transport chain (ETC) that connects all members of a microbiota while synchronously supporting massive metabolic versatility at a fraction of the overhead cost relative to conventional (single-celled) metabolism (Figure 1).…”

Section: Redefining Dysbiosismentioning

confidence: 99%

Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases

et al. 2021

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The conventional viewpoint of single-celled microbial metabolism fails to adequately depict energy flow at the systems level in host-adapted microbial communities. Emerging paradigms instead support that distinct microbiomes develop interconnected and interdependent electron transport chains that rely on cooperative production and sharing of bioenergetic machinery (i.e., directly involved in generating ATP) in the extracellular space. These communal resources represent an important subset of the microbial metabolome, designated here as the ''pantryome'' (i.e., pantry or external storage compartment), that critically supports microbiome function and can exert multifunctional effects on host physiology. We review these interactions as they relate to human health by detailing the genomic-based sharing potential of gut-derived bacterial and archaeal reference strains. Aromatic amino acids, metabolic cofactors (B vitamins), menaquinones (vitamin K2), hemes, and short-chain fatty acids (with specific emphasis on acetate as a central regulator of symbiosis) are discussed in depth regarding their role in microbiome-related metabolic diseases.

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“…The "golden age of antibiotics" in the mid-20th century was followed by the emergence of pathogens resistant to almost all available antibiotics, leading to the current global crisis of multidrug-resistant (MDR) bacteria (1,2). To identify successful alternative antimicrobial therapies, bacterial pathogenicity needs to be understood as a multifactorial issue in which the surrounded microbiota, which includes natural competitors and predators, is also involved (3). In nature, predatory bacteria play an important role in maintaining population sizes by linking the production and removal of biomass in microbial communities, which in turn promotes the diversity of microorganisms and contributes to the global stabilization of the ecosystem (4,5).…”

Section: Introductionmentioning

confidence: 99%

Predation Efficiency upon Clinical Isolates: Bdellovibrio bacteriovorus is Prey Specific and Origin Dependent

Herencias

Saralegui

Halperin

et al. 2021

Preprint

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The use of predatory bacteria as live antibiotics has been proposed for managing bacterial infections, especially for those caused by antibiotic multiresistant isolates for which there are few therapeutic options. However, the current knowledge in this field is scarce, with most of the available data based on environmental isolates, with a significant lack of human clinical samples. Here, we evaluated the predatory spectrum of the reference strain Bdellovibrio bacteriovorus 109J on 13 Serratia marcescens (including carbapenemase producers) and 78 Pseudomonas aeruginosa clinical isolates from respiratory (colonizing lungs of cystic fibrosis patients) or bacteremic infections, differentiated by phenotype (mucoid or not), antibiotic resistance phenotype (including multidrug-resistant isolates), and genetic lineage (frequent and rare sequence types). The source of the isolates was significantly associated with predation efficiency (100% for S. marcescens, 67% for P. aeruginosa from cystic fibrosis, and 25% for P. aeruginosa from bacteremia). In contrast, no correlation with colonial morphotype, genetic background, or antibiotic susceptibility was found. To evaluate the influence of the predator on the predation, we employed a more aggressive B. bacteriovorus mutant 109J preying upon the same 48 bacteremic P. aeruginosa isolates. The mutant's predation efficiency was higher than that of their wild-type counterpart (43% vs. 25%), pointing out that predation is specific to each prey-predator pair. Our results provide the most extensive study of clinical prey susceptibility published to date and show that the prey-predator interaction is influenced by the origin of the isolates rather than by their genetic background or their antibiotic susceptibility phenotype.

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Competitors versus Collaborators: Micronutrient Processing by Pathogenic and Commensal Human-Associated Gut Bacteria

Cited by 33 publications

References 44 publications

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases

Predation Efficiency upon Clinical Isolates: Bdellovibrio bacteriovorus is Prey Specific and Origin Dependent

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