Complement activation associated with transfusion related acute lung injury (TRALI)

Ambruso, Daniel R.; Giclas, Patricia C.; Silliman, C.; Kelher, Marguerite; Niedzinski, Jerry R; Geier, Steven S.

doi:10.1016/j.humimm.2005.08.036

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2013

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“…Animal studies indicate that complement activation is required for development of TRALI . Also, in clinical TRALI cases, complement activation contributes to the inflammatory cascade . Antibodies in transfused components may result in activation of the complement system .…”

Section: Introductionmentioning

confidence: 99%

“…Also, in clinical TRALI cases, complement activation contributes to the inflammatory cascade . Antibodies in transfused components may result in activation of the complement system . Possibly, the formation of immune complexes activates the complement system via the classical pathway; however, the exact route of complement activation in TRALI remains to be established.…”

Section: Introductionmentioning

confidence: 99%

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