Complement activation cascade triggered by PEG–PL engineered nanomedicines and carbon nanotubes: The challenges ahead

Moghimi, S. Moein; Andersen, Alina Joukainen; Hashemi, Sayed Hossein; Lettiero, Barbara; Ahmadvand, Davoud; Hunter, A. Christy; Andresen, Thomas Lars; Hamad, Islam; Szebeni, János

doi:10.1016/j.jconrel.2010.04.003

Cited by 155 publications

(97 citation statements)

References 44 publications

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“…Ancak, yalnızca sürfaktan veya PEG ile modifiye edilerek hedeflendirilen NP'lerin beyin ve periferlere zararlı olabileceğini gösteren birçok çalışma bulunmaktadır. 54 SONUÇ SSS, dış ve iç çevresinden gelen uyarıları algılaya-rak canlının yaşamını devam ettirmesi için gerekli hayati fonksiyonları yerine getiren nörolojik ağlar-dan oluşan bir sistemdir. SSS bu hayati fonksiyonlarını yerine getirme yeteneği nedeni ile korunaklı bir bölümde bulunmaktadır.…”

Section: İntravenöz Uygulamaunclassified

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Arısoy¹,

Sayiner²,

Çomoğlu³

2017

Turkiye Klinikleri J Pharm Sci

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Section: İntravenöz Uygulamaunclassified

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Arısoy¹,

Sayiner²,

Çomoğlu³

2017

Turkiye Klinikleri J Pharm Sci

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“…However, it has been reported that a high ligand density at the nanoparticle surface may promote idiosyncratic reactions based on complement activation and lead to a pseudo-allergic reaction (CARPA effect), which is responsible for thrombocytopenia, cardiopulmonary and hemodynamic changes that could conduce to death [43][44][45]. Therefore, SQdFdC/SQCKAAKN NPs and SQdFdC NPs were investigated for their ability of activating the complement C3 component, a key player in the activation of complement system [46].…”

Section: Complement Activation In Human Serummentioning

confidence: 99%

Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor

Valetti¹,

Maione

Mura

et al. 2014

Journal of Controlled Release

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Chemotherapy for pancreatic cancer is hampered by the tumor physio-pathological complexity. Here we show a targeted nanomedicine using a new ligand, the CKAAKN peptide, which had been identified by phage display, as an efficient homing device within the pancreatic pathological microenvironment. Taking advantage of the squalenoylation platform, the CKAAKN peptide was conjugated to squalene (SQCKAAKN) and then co-nanoprecitated with the squalenoyl prodrug of gemcitabine (SQdFdC) giving near monodisperse nanoparticles (NPs) for safe intravenous injection. By interacting with a novel target pathway, the Wnt-2, the CKAAKN functionalization enabled nanoparticles: (i) to specifically interact with both tumor cells and angiogenic vessels and (ii) to simultaneously promote pericyte coverage, thus leading to the normalization of the vasculature likely improving the tumor accessibility for the therapy. All together, this approach represents a unique targeted nanoparticle design with remarkable selectivity towards pancreatic cancer and multiple mechanism of action. Graphical abstract

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“…153 Another report suggests that PL-PEG moieties are responsible for complement activation by CNT, triggering the lectin pathway. 154 Being one of the most extensively studied and reviewed molecules, PEG and its interactions with various particles are being elaborately characterized and reported. This augurs well for the biomedical community.…”

Section: Stealth Carbon Nanotubesmentioning

confidence: 99%

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Kotagiri¹,

Kim²

2014

IJN

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Carbon nanotubes (CNTs) have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual elimination from the body; along with equally important issues such as aqueous solubility, dispersion, biocompatibility, and biofunctionalization. CNTs have not been shown to be able to evade such biological obstacles, which include their nonspecific attachments to cells and other biological components in the bloodstream, before reaching target tissues and cells in vivo. This will eventually determine their longevity in circulation and clearance rate from the body. This review article discusses the current status, challenges, practical strategies, and implementations of coating CNTs with biocompatible and opsonin-resistant moieties, rendering CNTs transparent to opsonins and deceiving the innate immune response to make believe that the CNTs are not foreign. A holistic approach to the development of such “stealth” CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of CNTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles. This review also discusses the present and potential applications, along with the future directions, of CNTs and their hybrid-based nanotheranostic agents for multiplex, multimodal molecular imaging and therapy, as well as in other applications, such as drug delivery and tissue engineering.

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Complement activation cascade triggered by PEG–PL engineered nanomedicines and carbon nanotubes: The challenges ahead

Cited by 155 publications

References 44 publications

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

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