The Complement System 1988
DOI: 10.1007/978-3-642-97038-2_2
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Complement and Complement Reactions

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Cited by 3 publications
(4 citation statements)
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“…When cells were exposed to RITC-chitosan in media containing 2% to 10% serum, a serum dose-dependent uptake was seen ( p < 0.05, Figure 11 A–B). Heat-inactivated FBS, which is depleted of complement activity and a number of important chemokines and growth factors [ 43 , 44 ], slightly suppressed mean cell fluorescence after 24 h of uptake (RITC-80M), without influencing the percent cells labeled ( Figure 11 A–B). All of the cultures carried out with 2% to 10% serum at pH 7.4 showed the same glucose consumption and slightly higher lactate generation than DMEM-only ( Figure 11 C).…”
Section: Resultsmentioning
confidence: 99%
“…When cells were exposed to RITC-chitosan in media containing 2% to 10% serum, a serum dose-dependent uptake was seen ( p < 0.05, Figure 11 A–B). Heat-inactivated FBS, which is depleted of complement activity and a number of important chemokines and growth factors [ 43 , 44 ], slightly suppressed mean cell fluorescence after 24 h of uptake (RITC-80M), without influencing the percent cells labeled ( Figure 11 A–B). All of the cultures carried out with 2% to 10% serum at pH 7.4 showed the same glucose consumption and slightly higher lactate generation than DMEM-only ( Figure 11 C).…”
Section: Resultsmentioning
confidence: 99%
“…Cleavage of the small peptide C3a from C3 generates a metastable C3b fragment with a reactive internal thioester bond that is able to form covalent linkages with activating surfaces 12. Solid‐phase C3b associates with the pro‐enzyme factor B to form a C3bB complex that is cleaved once in the factor B subunit by factor D; the Ba cleavage product dissociates leaving an active C3bBb solid‐phase convertase for C3 and C5 that locally amplifies the complement cascade 12, 15–17. C3b is rapidly cleaved in the alpha chain to form iC3b, by plasma protease I and its cofactor H,12, 17–19 and cell‐derived serine proteases can further degrade the iC3b alpha chain to produce C3c and C3dg 20, 21.…”
Section: Introductionmentioning
confidence: 99%
“…12 Solid-phase C3b associates with the proenzyme factor B to form a C3bB complex that is cleaved once in the factor B subunit by factor D; the Ba cleavage product dissociates leaving an active C3bBb solid-phase convertase for C3 and C5 that locally amplifies the complement cascade. 12,[15][16][17] C3b is rapidly cleaved in the alpha chain to form iC3b, by plasma protease I and its cofactor H, 12,[17][18][19] and cell-derived serine proteases can further degrade the iC3b alpha chain to produce C3c and C3dg. 20,21 As C3b and C3b break-down products remain associated with the activating surface as opsonins, complement activation can therefore be assayed by the appearance of fluid-phase C5a, and solid-phase associated C3b and break-down products.…”
Section: Introductionmentioning
confidence: 99%
“…= 1; p > 0.10). In the last group we observed 8 het erozygotes with 5 different variant alleles, 1 of which was anodal, another medium and the other 3 cathodal [12,30].…”
Section: Locusmentioning
confidence: 95%