1977
DOI: 10.1172/jci108763
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Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

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Cited by 653 publications
(157 citation statements)
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“…Other immunological changes have been associated with the HD procedure including the generation ofa plasma factor that augments granulocyte adherence (10,33), complement-mediated pulmonary leukostasis (34)(35)(36)(37), the presence of circulating free DNA (38), antinuclear antibodies (39), and anti-blood group N-like antibodies (40)(41)(42). Furthermore, cellulose membranes of the same type used in HD machinery have been shown to impair PMN random mobility (8).…”
Section: Cia In Hd Patient Serummentioning
confidence: 99%
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“…Other immunological changes have been associated with the HD procedure including the generation ofa plasma factor that augments granulocyte adherence (10,33), complement-mediated pulmonary leukostasis (34)(35)(36)(37), the presence of circulating free DNA (38), antinuclear antibodies (39), and anti-blood group N-like antibodies (40)(41)(42). Furthermore, cellulose membranes of the same type used in HD machinery have been shown to impair PMN random mobility (8).…”
Section: Cia In Hd Patient Serummentioning
confidence: 99%
“…Further studies will be essential to determine if this chemotactic inhibition like those previously described is associated with anergy, or involved in kidney transplant survival. Another common clinical situation that challenges HD patients is the respiratory distress associated with complement-mediated pulmonary leukostasis (34)(35)(36)(37). Studies indicate that C5a is responsible for HD-associated pulmonary leukostasis (37).…”
Section: Cia In Hd Patient Serummentioning
confidence: 99%
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“…Tem-se proposto que a agregação leucocitária induziria a ativação da cascata do complemento. Nestes casos, as manchas esbranquiçadas retinianas podem ser atribuídas a um extravasamento linfático secundário a um aumento da agregação de granulócitos, como resposta a ativação da fração 5 do complemento (18) .Trabalhos experimentais demonstraram a capacidade de agregação granulocitária do fator 5 do complemento uma vez que o anticorpo anti-C5 inibe completamente a agregação (19) .…”
Section: Fisiopatologiaunclassified
“…This interaction should be elevated the PMN binding activity in zymosan-treated serum. Furthermore, in the one-step method of the binding, the liberated fragments of the complement in the fluid phase, such as C5a, attract PMNs and increase their adhesive faculty (Craddock et al 1977). Zymosan-treated serum should contain such fragments in their active forms.…”
Section: Aggregated Rabbit Gammaglobulin (Arg)mentioning
confidence: 99%