Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid

Rampart, M.; Beetens, Johan; Bult, H; Herman, Arnold G.; Parnham, Michael J.; Winkelmann, Johannes

doi:10.1016/0006-2952(86)90289-3

Cited by 34 publications

(20 citation statements)

References 8 publications

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“…It has been shown to inhibit both the classical and the alternative pathways of complement activation [34, 35] and complement dependent stimulation of prostacyclin synthesis [36]. In vivo it is known to inhibit cobra venom factor-induced paw edema [33, 34].…”

Section: Discussionmentioning

confidence: 99%

“…Caffeic acid (3,4-dihydroxycinnamic acid) is one of the natural phenolic compounds widely distributed in plant materials such as vegetables, fruits, coffee, and tea [36]. This substance as an antioxidant can scavenge a number of reactive species, including 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) [25, 26], peroxyl [23], and hydroxyl radicals [24] as well as superoxide anion, peroxynitrite, and mutagenic compounds such as nitrosamines [24, 26].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats

et al. 2011

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Rosmarinic acid is commonly found in species of the Boraginaceae and the subfamily Nepetoideae (Lamiaceae). It has a number of interesting biological activities, for example, antiviral, antibacterial, anti-inflammatory, and antioxidant. The aim of the present study was to investigate the effect of the i.p. administration of caffeic and rosmarinic acid (5 and 10 mg/kg) on anti-inflammatory and nociceptive response using carrageenan-induced pleurisy model and tail-flick assay in rats. The analysis of cells in the pleural exudates revealed a reduction of 66% of the number of leukocytes that migrated to the pleural cavity in the animals treated with 5 mg/kg caffeic acid, and of 92.9% for the animals treated with 10 mg/kg in comparison with the control group. These exudates showed a balanced distribution of polymorphonuclear (PMN) and mononuclear (MN) cells, differently from the control group, in which PMN cells were predominant. The analysis to tail-flick latency was increased in the group treated with 10 mg/kg caffeic acid characterizing a nociceptive response. While there was no difference between control group and animals treated with rosmarinic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats

et al. 2011

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“…As such, elevations in hsCRP may be a strong indicator of cardiac stress [26]. Caffeic acid (3,4-dihydroxycinnamic acid) is one of the natural phenolic compounds widely distributed in plant materials such as vegetables, fruits, coffee, and tea [27]. This substance as an antioxidant can scavenge a number of reactive species, including 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) peroxyl, and hydroxyl radicals [28] as well as superoxide anion, peroxynitrite, and mutagenic compounds such as nitrosamines [29].…”

Section: Introductionmentioning

confidence: 99%

Effects of caffeic acid on doxorubicin induced cardiotoxicity in rats

Mohammad¹,

Aharis²,

Yousif³

et al. 2013

AJBM

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Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, its use is limited by the development of life-threatening cardiomyopathy.Doxorubicin generates free radicals and induces oxidative stress associated with cellular injury. Further, it has been shown that free radicals are involved in doxorubicin-induced toxicity. The goal of this study is to investigated the cardio-protective effects of caffeic acid on doxorubicin induced cardiotoxicity. The rats were randomized into three equal groups, sham group without treatment, doxorubicin treated group at a dose 3mg/kg IP every other two days and group treated with doxorubicin plus caffeic acid 40mg/day. Two weeks later LV function measurment were performed and blood samples were collected from the heart to measurment plasma levels of cardiac troponin-I (cTn-I), oxidative stress parameter malondialdehyde (MDA) and high a sensitive c-reactive protein (hs-CRP). The hearts were excised for cardiac tissue cytokines (TNF-α, IL-1β, IL-10) measurement and microscopic examination. Rats in the Dox+caffeic acid group had improved LV function, reduced cytokine expression, decreased myocardial marker injury (cTn-I) and less MDA, hs-CRP levels in comparison with the Dox group. Pathological finding appeared nearly normal in the Dox+caffeic acid without fibrosis. The results of the present study reveal that caffeic acid has a promising cardioprotective effect against doxorubicin-induced cardiotoxicity.

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“…For rosmarinic acid, the inhibition of several complement-dependent inflammatory processes has been widely studied (Rampart et al, 1986;Engleberger et al, 1988;). Whereas rosmarinic acid is found in substantial quantities in several species in the family Lamiaceae, it is also widespread in other families such as Borangiaceae (De-Eknamkul & Ellis, 1984;Shetty, 1997).…”

Section: Introductionmentioning

confidence: 99%

Phenolic Antioxidant Compounds Produced byin Vitro. Cultures of Rosemary (Rosmarinus officinalis.) and Their Anti-inflammatory Effect on Lipopolysaccharide-Activated Microglia

Kuhlmann

Röhl

2006

Pharmaceutical Biology

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Different culture types (shoot culture, callus culture, and cell suspension culture) of Rosmarinus officinalis L. were established and their ability to biosynthesize the phytochemicals carnosic acid, carnosol, and rosmarinic acid were assessed and compared with subcultures of the same stem plant over time. Furthermore, we examined the antioxidative effect of extracts from different culture types by measuring their scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals as well as their anti-inflammatory potential on neonatal microglial rat cells activated by means of the inflammogen lipopolysaccharide (LPS) taking nitric oxide (NO) as parameter. Our results show that during an investigation period of 17 months, the shoot culture accumulated varying amounts of carnosic acid and carnosol, which were also present in callus culture but about 20-to 80-fold lower than in the shoot culture. In suspension culture, only carnosic acid and no carnosol could be detected. The level of carnosic acid in suspension culture was threefold less than detected for the callus culture on average. The amount of rosmarinic acid produced in shoot culture and callus culture were comparable, whereas in suspension culture higher concentrations of rosmarinic acid could be measured than in shoot and callus culture. Thus, the content of carnosic acid, carnosol, and rosmarinic acid in the extracts depended on the differentiation grade of the cell culture type. The DPPH radical-scavenging activity of the extracts depended on the amount of all three phytochemicals, in particular of rosmarinic acid. The anti-inflammatory character of the extracts was mainly based on their carnosic acid content.

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Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid

Cited by 34 publications

References 8 publications

Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats

Effect of Rosmarinic and Caffeic Acids on Inflammatory and Nociception Process in Rats

Effects of caffeic acid on doxorubicin induced cardiotoxicity in rats

Phenolic Antioxidant Compounds Produced byin Vitro. Cultures of Rosemary (Rosmarinus officinalis.) and Their Anti-inflammatory Effect on Lipopolysaccharide-Activated Microglia

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