“…A large number of other complement-mediated disorders are known, and in many situations indications were found for the importance of the MAC. They include inflammation caused by trauma (49), rheumatoid arthritis (50), macular degeneration (51,52), hemolytic anemias (53,54), nephritis (55,56), and demyelinating neuropathies such as multiple sclerosis and Guillain-Barré syndrome (57,58). In rodent models, MAC formation increased the severity of rheumatoid arthritis, whereas a CD59 derivative decreased it (59,60).…”