2008
DOI: 10.1111/j.1365-2249.2008.03830.x
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Complement in multiple sclerosis: its role in disease and potential as a biomarker

Abstract: SummaryMultiple sclerosis (MS) is a common inflammatory disease of the central nervous system with a poorly defined and complex immunopathogenesis. Although initiated by reactive T cells, persistent inflammation is evident throughout the disease course. A contribution from complement has long been suspected, based on the results of pathological and functional studies which have demonstrated complement activation products in MS brain and biological fluids. However, the extent and nature of complement activation… Show more

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Cited by 99 publications
(96 citation statements)
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References 138 publications
(146 reference statements)
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“…A large number of other complement-mediated disorders are known, and in many situations indications were found for the importance of the MAC. They include inflammation caused by trauma (49), rheumatoid arthritis (50), macular degeneration (51,52), hemolytic anemias (53,54), nephritis (55,56), and demyelinating neuropathies such as multiple sclerosis and Guillain-Barré syndrome (57,58). In rodent models, MAC formation increased the severity of rheumatoid arthritis, whereas a CD59 derivative decreased it (59,60).…”
Section: Discussionmentioning
confidence: 99%
“…A large number of other complement-mediated disorders are known, and in many situations indications were found for the importance of the MAC. They include inflammation caused by trauma (49), rheumatoid arthritis (50), macular degeneration (51,52), hemolytic anemias (53,54), nephritis (55,56), and demyelinating neuropathies such as multiple sclerosis and Guillain-Barré syndrome (57,58). In rodent models, MAC formation increased the severity of rheumatoid arthritis, whereas a CD59 derivative decreased it (59,60).…”
Section: Discussionmentioning
confidence: 99%
“…There is compelling evidence that complement activation contributes to the pathogenesis of autoimmune diseases like systemic lupus erythematosus, multiple sclerosis or rheumatoid arthritis (Ingram et al, 2009). An important finding of this study was the systemic and local upregulation of FB ( Fig.…”
Section: Discussionmentioning
confidence: 99%
“…AchE is a key enzyme responsible for the hydrolysis of acetylcholine, an essential neurotransmitter re- [21]. The complement system, an important part of the innate immune system with a wide range of effects in multiple disease states in the CNS, could play such a contributory role [22]. The compounds which are high scoring against Acetylcholine-esterase target protein act by inhibiting the active site, thus suppressing the AchE action, leading to stimulant effect.…”
Section: Interaction With Acetylcholinesterase Target Proteinmentioning
confidence: 99%