Complement studies in children with treated coeliac disease after gluten challenge

Bosch, Ch.; Becker, Manfred; Rotthauwe, H. W.; Opferkuch, W.

doi:10.1007/bf01846034

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The values of 132M were 1.94 ± 0.49 mg/L in group A (inactive CD with normal intestinal biopsy) and 2.58 ± 0.76 mg/L in group B (active CD with flat mucosa). These levels were higher than in the normal controls (1.87 ± 0.49 mg/L , p < 0 .005) and in the other 19 pati ents with chro nic di arrhea of another cau se…”

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confidence: 53%

“…An immunological mechanism is presumed in CD. Circulating immunocomplexes, antibodies against gluten, antireticulin antibodies, and complement and immunoglobulin abnormalities have previously been reported, but their relevance to CD pathogene sis remains unproven (17)(18)(19)(20) . An implication of cell-mediated immunity seems more likely (12).…”

Section: Discussionmentioning

confidence: 99%

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Increased Serum β₂‐Microglobulin Levels in Active Celiac Disease

Blanco,

Alonso,

Cilleruelo

et al. 1985

J. pediatr. gastroenterol. nutr.

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Sixty‐eight sera from 36 children with celiac disease (CD) were collected in a 4‐year study, and the levels of β2‐microglobulin (β2M), orosomucoid, α1‐antitrypsin, and C‐reactive protein (CRP) were measured. A simultaneous intestinal biopsy was taken in all the patients and used to classify them. The values of (β2M were 1.94 ± 0.49 mg/L in group A (inactive CD with normal intestinal biopsy) and 2.58 ± 0.76 mg/L in group B (active CD with flat mucosa). These levels were higher than in the normal controls (1.87 ± 0.49 mg/L, p < 0.005) and in the other 19 patients with chronic diarrhea of another cause (1.72 ± 0.63 mg/L, p < 0.005). CRP values were generally normal; orosomucoid and α‐antitrypsin were variable and they did not correlate with β2M levels. β2M was increased at the time of diagnosis in seven of eight (87.5%) of the CD children and only in three of 19 (15.7%) of nonceliac patients with chronic diarrhea of another cause (p < 0.005). In 12 children with CD, serial studies were possible. The highest β2M level coincided with a flat mucosa in 10 cases. The increase of β2M could be related to the intestinal infiltration or even to the lymphocyte activation. It may also be a useful noninvasive method for evaluating the activity of CD.

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mentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Increased Serum β₂‐Microglobulin Levels in Active Celiac Disease

Blanco,

Alonso,

Cilleruelo

et al. 1985

J. pediatr. gastroenterol. nutr.

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Detection of Gluten in Human Sera by an Enzyme Immunoassay: Comparison of Dermatitis Herpetiformis and Celiac Disease Patients with Normal Controls

Lane

Huff

Weston

1982

Journal of Investigative Dermatology

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We have developed a triple sandwich enzyme immunoassay to detect circulating gluten in human sera. With human sera containing known amounts of added gluten as controls, the assay was sensitive in the range of 0.75 to 75 micrograms of gluten per ml of serum. Forty-one control subjects were compared to 21 patients with dermatitis herpetiformis and 11 patients with celiac disease. The dermatitis herpetiformis and celiac disease patients had significant elevation of serum gluten values over the control subjects. Circulating gluten antigenemia is a previously unrecognized feature which may be important in understanding the pathogenesis of dermatitis herpetiformis and celiac disease.

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