Recent research shows that tango dance may be an effective strategy for influencing symptoms that contribute to mood disorders. In this study, we examined the efficacy of a short-duration intensive tango program (ie, 2 weeks). Forty-one participants were randomized to tango dance (1½ hours, 4 times/week for 2 weeks) or to a wait-list control condition. Self-rated symptoms of depression, anxiety, stress, insomnia, self-efficacy, satisfaction with life and mindfulness were assessed at pretest, posttest, and 1 month later. Tango group participants showed significant reductions in depression, anxiety, stress, and insomnia at posttest relative to the controls, whereas satisfaction with life and self-efficacy were significantly increased. At 1-month follow-up, depression, anxiety, and stress levels remained reduced relative to the wait-list controls. Thus, this brief but intensive program of tango dance was shown to be an effective strategy in alleviating mood disorders in people who self-report these symptoms.