Complete genome analysis of coxsackievirus A24 isolated in Yunnan, China, in 2013

Zhao, Yilin; Liu, Jiansheng; Zhang, Haihao; Xia, Longhui; Yang, Fang; Yang, Huai; Yang, Qinxing; Yang, Zhaoqing; Ma, Shaohui

doi:10.1007/s00705-016-2792-0

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…During the study period, there were two peaks of AHC incidence, in 2007 and 2010 [ 17 ]. Since 1971, Cox24v has been the major pathogen of AHC in China [ 47 ]. The outbreaks caused by CA24v are usually more widespread than those caused by EV70 [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological trends and sociodemographic factors associated with acute hemorrhagic conjunctivitis in mainland China from 2004 to 2018

Liu

Chen

et al. 2022

Virol J

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Background Acute hemorrhagic conjunctivitis (AHC) is classified as a class C notifiable infectious disease in China and poses a great threat to public health. This study aimed to investigate the epidemiological trends and hotspots of AHC in mainland China. Sociodemographic factors that could contribute to early warning of AHC were further explored. Methods Yearly and monthly incidences of acute hemorrhagic conjunctivitis by date and region from 2004 to 2018 were extracted from the Data Center of China Public Health Science. Joinpoint regression and spatial autocorrelation analysis were performed to explore the epidemiological trends and hotspots of AHC. A generalized linear model was then applied to explore the relationship between sociodemographic factors and AHC incidence. Results The average annual AHC incidence was 3.58/100,000 in mainland China. The first-level spatial and temporal aggregation areas were distributed in Guangxi, Hainan, Guangdong, Guizhou, Hunan, Jiangxi, Fujian, Chongqing, Hubei, Anhui, and Zhejiang, with gathering times from 2010/1/1 to 2010/12/31 (RR = 20.13, LLR = 474,522.89, P < 0.01). After 2010, the AHC incidence was stable (APC = − 8.37, 95% CI: − 23.02–9.06). However, it was significantly increased in low- and middle-income provinces (AAPC = 10.65, 95% CI: 0.62–21.68, AAPC = 11.94, 95% CI: 0.62–24.53). The peak of AHC occurred during the August to October period. Children who age 0–3 years are identified as high-risk group with AHC incidence significantly increased (APC = 31.54, 95% CI: 0.27–72.56). Birth rate, population ages 0–14 (% of total population), passenger traffic, and urban population (% of total population) were positively associated with the AHC incidence, while per capita gross domestic product was negatively associated with the AHC incidence. Conclusion Overall, the AHC incidence was stable after 2010 in China, but it was significantly increased in low- and middle-income provinces. Regions with a high birth rate, population ages 0–14 (% of the total population), passenger traffic, urban population (% of the total population) and low per capita gross domestic product are at high risk of incidences of AHC. In the future, public health policy and resource priority for AHC in regions with these characteristics are necessary.

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Section: Discussionmentioning

confidence: 99%

Epidemiological trends and sociodemographic factors associated with acute hemorrhagic conjunctivitis in mainland China from 2004 to 2018

Liu

Chen

et al. 2022

Virol J

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“…For example, coxsackievirus infections in infants can result in hand-foot-and-mouth disease, myocarditis, meningitis, and encephalitis [ 19 ]. Coxsackievirus A24 and enterovirus 70 are associated with acute hemorrhagic conjunctivitis [ 20 ]. Recently, some high virulent strains of enteroviruses have emerged and became a severe threat to children worldwide.…”

Section: Discussionmentioning

confidence: 99%

Risk of Nephrotic Syndrome following Enteroviral Infection in Children: A Nationwide Retrospective Cohort Study

Lin

Yang

et al. 2016

PLoS ONE

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PurposeNephrotic syndrome is a common chronic illness encountered during childhood. Infections have been identified as a cause of nephrotic syndrome. The aim of this study was to evaluate the association between enteroviral infection and nephrotic syndrome.MethodsA nationwide retrospective cohort study was conducted by analyzing data from the National Health Insurance Research Database in Taiwan. Children aged <18 years with enteroviral infection were enrolled. Non-enterovirus-infected children were randomly selected as the comparison cohort. The primary endpoint was the occurrence of nephrotic syndrome.MethodsThis study included 280,087 enterovirus-infected children and 280,085 non-enterovirus-infected children. The mean age of the enterovirus-infected children was 2.38 years, and 53.7% of these children were boys. The overall incidence densities of nephrotic syndrome for enterovirus- and non-enterovirus-infected children were 2.65 and 2.21 per 10,000 person-years, respectively. The enterovirus-infected cohort had a higher cumulative incidence of nephrotic syndrome than did the non-enterovirus-infected cohort (log-rank test, p = 0.01). Multivariable analyses revealed that children with enteroviral infection were significantly associated with an increased risk of nephrotic syndrome compared with those without enteroviral infection (adjusted hazard ratio, 1.20; 95% confidence interval, 1.04–1.39; p = 0.01), particularly in children infected with coxsackievirus. Subgroup analyses revealed that enterovirus-infected girls, children of blue-collar workers, and children without allergies had a higher risk of nephrotic syndrome than did children in the non-enterovirus-infected cohort.ConclusionThis study revealed a significant association between enteroviral infection and nephrotic syndrome. Additional studies elucidating the role and pathogenesis of enterovirus in nephrotic syndrome are warranted.

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“…EV‐C mainly contains poliovirus types 1–3 (PV1–3), some group A coxsackieviruses (CVA1, 11, 13, 17, 19–22, and 24), and some recently discovered EV (EV‐C95, 96, 99, 102, 104, 105, 109, 113, and 116–118), totaling 23 serotypes 1 . In addition to poliomyelitis caused by PV, the recent discovery of new EVs has gradually aroused attention, such as CVA24 variant strain (CVA24v), which causes acute hemorrhagic conjunctivitis 2 . Enterovirus C96 (EV‐C96) is a recently discovered EV; the prototype strain (strain BAN00‐10488) was isolated from a fecal specimen of a patient with acute flaccid paralysis (AFP) in Bangladesh in 2000 3 .…”

Section: Introductionmentioning

confidence: 99%

Characterizing enterovirus C96 genome and phylodynamics analysis

Yang,

Sun,

Yan

et al. 2023

Journal of Medical Virology

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Enterovirus C96 (EV‐C96) is a recently discovered serotype belonging to enterovirus C species. It had been isolated from patients with acute flaccid paralysis, hand, foot, and mouth disease, diarrhea, healthy people, or environmental specimens. Despite increasing reports of the virus, the small number of full‐length genomes available for EV‐C96 has limited molecular epidemiological studies. In this study, newly collected rare EV‐C96 strains in China from 1997 to 2020 were combined with sequences available in GenBank for comprehensive analyses. Sequence analysis revealed that the nucleotide sequence similarity of EV‐C96 and the prototype strain (BAN00‐10488) was 75%–81.8% and the amino acid sequence similarity was 85%–94.9%. EV‐C96 had a high degree of genetic variation and could be divided into 15 genogroups. The mean evolutionary rate was 5.16 × 10−3 substitution/site/year, and the most recent common ancestor was dated to 1925. A recombination analysis revealed that EV‐C96 may be a recombinant derived from other serotypes in the EV‐C group in the nonstructural protein coding region. This comprehensive and integrated analysis of the whole genome sequence of EV‐C96 provides valuable data for further studies on the molecular epidemiology of EV‐C96 worldwide.

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Complete genome analysis of coxsackievirus A24 isolated in Yunnan, China, in 2013

Cited by 8 publications

References 27 publications

Epidemiological trends and sociodemographic factors associated with acute hemorrhagic conjunctivitis in mainland China from 2004 to 2018

Epidemiological trends and sociodemographic factors associated with acute hemorrhagic conjunctivitis in mainland China from 2004 to 2018

Risk of Nephrotic Syndrome following Enteroviral Infection in Children: A Nationwide Retrospective Cohort Study

Characterizing enterovirus C96 genome and phylodynamics analysis

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