Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives

Steinbrecher, Urs P.; Lisbona, Robert; Huang, Sidong; Mishkin, Seymour

doi:10.1007/bf01314771

Cited by 80 publications

(35 citation statements)

References 20 publications

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“…During its natural evolution, HCA may remain stable, increase in size, or regress (49)(50)(51)(52). Regression is more frequently described in HCA related to androgenic-anabolic steroids and glycogenosis after hormone withdrawal, or after an appropriate alimentary regiment (53)(54)(55)(56).…”

Section: -Clinical and Pathological Characteristics Of Hcamentioning

confidence: 99%

Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma

Rebouissou¹,

Bioulac‐Sage²,

Zucman‐Rossi³

2008

Journal of Hepatology

223

142

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Section: -Clinical and Pathological Characteristics Of Hcamentioning

confidence: 99%

Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma

Rebouissou¹,

Bioulac‐Sage²,

Zucman‐Rossi³

2008

Journal of Hepatology

223

142

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“…So cessation of oral contraceptive is still necessary. 20 Besides, the tumor progression is associated with increased risk of bleeding or rupture, the treatment of hepatic adenoma is surgical resection when possible. If patient presents with multiple hepatic adenoma, complete resection may be impossible, and hepatic transplantation is taken into consideration when tumors progress.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Adenoma - A Case Report

et al. 2016

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We report the case of a 32-year-old female who presented to us with incidental findings of a space occupying lesion (SOL) in liver on abdominal ultrasound (USG). She was taking oral contraceptive pill for last 9 years. Clinical examination was unremarkable and liver investigation revealed mildly raised Serum alanine aminotrasferase (ALT). Dyslipidemia was also present. Computed tomography (CT) identified a 2.5 cm lesion in the right lobe of liver at posterior aspect which was isodense. Alpha-feto protein was normal. CT guided Fine Needle Aspiration Cytology (FNAC) showed adequate cellular material containing organized reactive hepatocytes in the background of blood. No granuloma or malignant cell was seen. Findings were suggestive of hepatic adenoma.Birdem Med J 2015; 5(1) Supplement: 59-62

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“…Rupture with intraabdominal hemorrhage may occur in up to one third of patients and typically occurs in patients who are taking oral contraceptives and have large, solitary t u m o r~.~.~ Hepatocellular adenomas have been shown to regress on cessation of estrogen treatment. [19][20][21][22] However, some tumors may grow in size after stopping hormonal the rap^.^^,*^ A rare but serious complication of hepatocellular adenomas is transformation into hepatocellular carcinoma.j-" Subtle vascular encasement identified during diagnostic hepatic arteriography in case no. 1 prompted serial imaging studies while waiting for OLT, although the sensitivity of hepatic imaging studies to identify malignant degeneration of an hepatocellular adenoma is unknown.…”

Section: Discussionmentioning

confidence: 99%

Liver Transplantation for Treatment of Giant Hepatocellular Adenomas

1995

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Giant hepatocellular adenomas are associated with a high incidence of rupture with intraabdominal hemorrhage and may also undergo malignant transformation. If resection is not technically feasible, liver transplantation should be a treatment option. The aim of this report is to describe the indications, feasibility, and outcome of liver transplantation for hepatocellular adenomas. A 66‐year‐old man with a 17‐cm hepatocellular adenoma originating in the left lobe but involving nearly the entire liver and a 35‐year‐old woman with a 20‐cm tumor involving the right lobe of the liver and compressing the left lobe underwent liver transplantation without complication. In both cases, a histological diagnosis was made by core needle biopsy preoperatively, and resection was technically not possible. Hepatocellular adenoma involving nearly all of the liver with no evidence of malignant change was confirmed in the explant liver from both cases. Giant hepatocellular adenomas may be unresectable and require liver transplantation for complete removal to prevent potential rupture with hemorrhage or malignant transformation Copyright © 1995 by the American Association for the Study of Liver Diseases.

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Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives

Cited by 80 publications

References 20 publications

Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma

Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma

Hepatic Adenoma - A Case Report

Liver Transplantation for Treatment of Giant Hepatocellular Adenomas

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