Complete Remission of Severe Diabetes

Peck, Franklin B.; Kirtley, W R

doi:10.2337/diab.7.2.93

Cited by 23 publications

(11 citation statements)

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“…Temperature 100. 2 Her level of consciousness did not return to normal for forty-eight hours. She was intermittently febrile during the first forty-eight hours and was treated empirically with penicillin for four days, without focal signs or cultural evidence of infection.…”

Section: Methodsmentioning

confidence: 97%

“…1 In adults, a number of reports have cited long-lasting complete or partial remissions in diabetes after recovery from the initial acute episode. 2 " 8 The purpose of this report is to present studies of insulin secretion in two adult cases of remittent diabetes whose disease began with spontaneous ketoacidosis. The results demonstrate that clinical remission is characterized by a return of endogenous insulin and point to the potentially reversible nature of beta cell dysfunction.…”

mentioning

confidence: 99%

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Clinical Remission in Diabetes Mellitus: Studies of Insulin Secretion

Genuth

1970

Diabetes

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Section: Methodsmentioning

confidence: 97%

mentioning

confidence: 99%

Clinical Remission in Diabetes Mellitus: Studies of Insulin Secretion

Genuth

1970

Diabetes

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“…Following intensive treatment of blood glucoses over several months, antidiabetic pharmacologic agents were gradually withdrawn and, although no significant weight loss occurred, blood glucose levels remained normal. This phenomenon was initially described in African Americans and has subsequently been observed in other groups, including Japanese and European populations [5,[19][20][21][22][23][24][25][26]. Remission is defined as a fasting blood glucose less than 126 mg/dL and hemoglobin A 1c (HbA 1c ) levels within normal limits for 3 months in a patient with type 2 diabetes who has discontinued active pharmacologic treatment.…”

Section: Remission and Recovery Of Metabolic Homeostasismentioning

confidence: 97%

Diabetes in African Americans: Unique pathophysiologic features

Banerji

2004

Curr Diab Rep

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Type 2 diabetes is an increasing public health problem among African Americans, especially children. Several features make type 2 diabetes among African Americans unique. First, African-American adults with type 2 diabetes, or Flatbush diabetes, present with diabetic ketoacidosis. Patients are insulin resistant with acute, severe defects in insulin secretion and no islet cell autoantibodies. Following treatment, some insulin secretory capacity is recovered and ketoacidosis generally does not recur. The second is remission in African Americans with type 2 diabetes. Recovery of glucose homeostasis, accompanied by recovery of beta-cell function, follows intensive glycemic regulation. Finally, among African Americans with diabetes who are not obese, normal insulin sensitivity is not uncommon. Such individuals do not have the increased cardiovascular risk of insulin-resistant individuals. Differences in visceral, not subcutaneous, adipose tissue volume appear to determine insulin sensitivity. Understanding the unique physiologic and clinical features of African Americans is critical in designing appropriate treatment strategies.

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“…[1][2][3][4][5] Acute presentation with or without ketoacidosis has been reported in certain ethnic groups like Asians and African Americans. [6][7][8][9] There have been a few reports of normoglycemic remissions following intensive control of blood glucose with insulin [10][11][12] and oral hypoglycemic agents (OHAs) in the subgroup of patients with such acute presentations.…”

Section: Introductionmentioning

confidence: 99%