Complete Tumor Response of Tracheal Squamous Cell Carcinoma After Treatment With Pembrolizumab

Maller, Bradley; Kaszuba, Frank J.; Tanvetyanon, Tawee

doi:10.1016/j.athoracsur.2018.08.067

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…And PD-L1 overexpression also means that the patient may be sensitive to PD-L1 inhibitor. There have been 2 case reports showing the successful use of immune therapy in tracheal SCC with significant PD-L1 expression (21,22). Specifically, the patients were treated with nivolumab and pembrolizumab respectively, and both of them obtained completed tumor response after several months.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the application of PD-1 or PD-L1 inhibitors has been approved in multiple tumors (16), including non-small cell lung cancer (17), head and neck cancer (18), melanoma (19), and breast cancer (20). In recent years, several case reports have shown that patients with tracheobronchial neoplasm can benefit from PD-1 inhibitors, nivolumab and pembrolizumab (21)(22)(23). And SCC of primary tracheobronchial neoplasm was found to have significant PD-L1 expression, even 95% of tumor cells (22).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, several case reports have shown that patients with tracheobronchial neoplasm can benefit from PD-1 inhibitors, nivolumab and pembrolizumab (21)(22)(23). And SCC of primary tracheobronchial neoplasm was found to have significant PD-L1 expression, even 95% of tumor cells (22). This indicated that immunotherapy may be a potential alternative treatment for patients with unresectable tracheobronchial neoplasms.…”

Section: Introductionmentioning

confidence: 99%

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PD-L1 expression and immune cells infiltration in primary tracheobronchial neoplasm

Zheng¹,

Liu²,

Ma³

et al. 2021

Transl Lung Cancer Res

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Background: Primary tracheobronchial neoplasm is rare yet poses a serious threat to life. Due to its low incidence, the immune microenvironment of such tumors remained unclear. This study aimed to clarify the expression of programmed death-ligand 1 (PD-L1) and infiltration of immune cells in primary tracheobronchial neoplasm, which might be useful for guiding treatment and evaluating clinical outcome. Methods:We assessed retrospectively the expression of PD-L1 and infiltration in cells expressing CD8, CD16, CD68, CD163 and FOXP3 in 21 patients with primary tracheobronchial neoplasm who underwent surgery in Tangdu Hospital from January 2016 to July 2021. The expression of PD-L1 was assessed based on the tumor proportion score system. The density of immune cells was analyzed by automatic image analysis software.Results: In this study, all of 16 participants with adenoid cystic carcinoma (ACC) had no expression of PD-L1, whereas 4/5 (80%) of those with squamous cell carcinomas (SCC) were positive for PD-L1 expression.Compared with ACC, the density of FOXP3 + cells in both the intratumoral region and peritumoral region was higher in SCC (P<0.01). The density of FOXP3 + cells was significantly higher than that of CD8 + , CD16 + , and CD163 + cells in SCC in the intratumoral region (P<0.01). In contrast, the density of FOXP3 + cells was significantly lower than that of CD8 + , CD16 + , and CD68 + cells in ACC in both the intratumoral region and peritumoral regions. The density of CD68 + cells was significantly higher than that of CD8 + cells (P<0.05) and CD163 + cells (P<0.01) in ACC in the intratumoral region. Furthermore, the tumors of patients with metastasis more commonly of immune-excluded status, in which the CD8 + cells accumulated in peritumoral region.Conclusions: This study demonstrated that the expression of PD-L1 in primary tracheobronchial neoplasm was mainly concentrated in patients with SCC. In the immune microenvironment of SCC, FOXP3 + cells were the dominant immune cells, while in the immune microenvironment of ACC, CD68 + 2 Zheng et al. The immune microenvironment of tracheobronchial neoplasm

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

PD-L1 expression and immune cells infiltration in primary tracheobronchial neoplasm

Zheng¹,

Liu²,

Ma³

et al. 2021

Transl Lung Cancer Res

View full text Add to dashboard Cite

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“…According to the present reported cases, patients with lung cancer for tislelizumab were extremely rare [ 6 , 12 ], and we did not find any case report with a significant response or even complete response in SCC treated with tislelizumab. Similarly, a few cases show the effectiveness of pembrolizumab for lung SCC [ 13 – 15 ].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of two patients with unresectable lung squamous cell carcinoma with tislelizumab regardless of programmed death-ligand 1 expression: a report of two cases

Cao

et al. 2021

Anti-Cancer Drugs

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Since the treatment of lung squamous cell carcinoma (SCC) was limited due to a lack of appropriate biomarkers and novel target agents. Immune checkpoint inhibitors can offer an effective treatment for patients with advanced non-small cell lung cancer. Here, we described the cases of two patients with SCC who showed a good response following treatment with tislelizumab. We encountered two patients with unresectable lung SCC who were treated with immunotherapy and chemotherapy. One patient had negatively programmed death-ligand 1 expression, and the primary lesion becomes a thick wall cavity after the tislelizumab combined with chemotherapy. Another patient was diagnosed with advanced lung SCC with negative programmed death-ligand 1 expression. After the treatment, the fluorine-18-fluorodeoxyglucose PET/computed tomography indicated that no abnormal increase in radioactivity uptake and tend to complete remission. We found a significant response or even complete response in unresectable SCC treated with tislelizumab combined with chemotherapy. Our cases added evidence of the feasibility and efficacy of tislelizumab combined with chemotherapy in unresectable lung SCC.

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“…The airway epithelium serves as an interaction surface between the organism and a harsh environment, and its normal physiological function is vital for the host's wellbeing. Diseases that involve tracheal tissues include congenital tracheal anomalies [1], tracheal neoplasm [2], infection [3], inflammation [4], trauma, and post-intubation injuries [5]. Treatments utilizing foreign materials such as titanium mesh [6,7], naturally derived materials such as cellulose [8], nonviable allograft [9], tissue engineering [10] and various types of tracheal transplantation have been tried.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Feasibility of Human Tissue Engineered Respiratory Epithelium Construct as a Potential Model for Tracheal Mucosal Reconstruction

et al. 2021

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The normal function of the airway epithelium is vital for the host’s well-being. Conditions that might compromise the structure and functionality of the airway epithelium include congenital tracheal anomalies, infection, trauma and post-intubation injuries. Recently, the onset of COVID-19 and its complications in managing respiratory failure further intensified the need for tracheal tissue replacement. Thus far, plenty of naturally derived, synthetic or allogeneic materials have been studied for their applicability in tracheal tissue replacement. However, a reliable tracheal replacement material is missing. Therefore, this study used a tissue engineering approach for constructing tracheal tissue. Human respiratory epithelial cells (RECs) were isolated from nasal turbinate, and the cells were incorporated into a calcium chloride-polymerized human blood plasma to form a human tissue respiratory epithelial construct (HTREC). The quality of HTREC in vitro, focusing on the cellular proliferation, differentiation and distribution of the RECs, was examined using histological, gene expression and immunocytochemical analysis. Histological analysis showed a homogenous distribution of RECs within the HTREC, with increased proliferation of the residing RECs within 4 days of investigation. Gene expression analysis revealed a significant increase (p < 0.05) in gene expression level of proliferative and respiratory epithelial-specific markers Ki67 and MUC5B, respectively, within 4 days of investigation. Immunohistochemical analysis also confirmed the expression of Ki67 and MUC5AC markers in residing RECs within the HTREC. The findings show that calcium chloride-polymerized human blood plasma is a suitable material, which supports viability, proliferation and mucin secreting phenotype of RECs, and this suggests that HTREC can be a potential candidate for respiratory epithelial tissue reconstruction.

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Complete Tumor Response of Tracheal Squamous Cell Carcinoma After Treatment With Pembrolizumab

Cited by 7 publications

References 8 publications

PD-L1 expression and immune cells infiltration in primary tracheobronchial neoplasm

PD-L1 expression and immune cells infiltration in primary tracheobronchial neoplasm

Successful treatment of two patients with unresectable lung squamous cell carcinoma with tislelizumab regardless of programmed death-ligand 1 expression: a report of two cases

Evaluating Feasibility of Human Tissue Engineered Respiratory Epithelium Construct as a Potential Model for Tracheal Mucosal Reconstruction

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