Completely Superhydrophobic PDMS Surfaces for Microfluidics

Tropmann, A.; Tanguy, Laurent; Koltay, Peter; Zengerle, Roland; Riegger, L.

doi:10.1021/la301283m

Cited by 143 publications

(76 citation statements)

References 22 publications

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“…[7] Critically, substrates possessing bulk rigidity of circa 20-50 kPa have been previously shown to induce stem cell differentiation to cartilage and bone specific lineages in vitro. [7,17] Poly(dimethylsiloxane) (PDMS), in particular, has recently found widespread use in cell adhesion/migration assays [18] microfluidic and MEMS technologies [19] due to its favorable optical, biocompatible and mechanical properties. Indeed, PDMS substrates have been used to study the role of extracellular rigidity on cellular adhesion [20] and differentiation, [21] due to the ease by which its rigidity may be precisely controlled by simply varying the base:accelerator ratio.…”

Section: Introductionmentioning

confidence: 99%

The Functional Response of Mesenchymal Stem Cells to Electron‐Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity

et al. 2017

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Biggs, M. J. P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.Biggs, M. J.P. et al. (2017) AbstractCells directly probe and respond to the physicomechanical properties of their extracellular environment, a dynamic process which has been shown to play a key role in regulating both cellular adhesive processes and differential cellular function. Recent studies indicate that stem cells show lineage-specific differentiation when cultured on substrates approximating the stiffness profiles of specific tissues. Although tissues are associated with ranging Young's modulus values for bulk rigidity, at the sub-cellular level, and particularly at the micro-and nanoscales, tissues are comprised of heterogeneous distributions of rigidity.Lithographic processes have been widely explored in cell biology for the generation of analytical substrates to probe cellular physicomechanical responses. In this work, we show for the first time that that direct-write e-beam exposure can significantly alter the rigidity of elastomeric PDMS substrates and develop a new class of two-dimensional elastomeric substrates with controlled patterned rigidity ranging from the micron to the nanoscale. The mechano-response of human mesenchymal stem cells to e-beam patterned substrates was subsequently probed in vitro and significant modulation of focal adhesion formation and osteochondral lineage commitment was observed as a function of both feature diameter and rigidity, establishing the groundwork for a new generation of biomimetic material interfaces.3

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Section: Introductionmentioning

confidence: 99%

The Functional Response of Mesenchymal Stem Cells to Electron‐Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity

et al. 2017

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“…[ 1 ] Such a surface exhibits both theoretical importance and practical applicability in areas including biology, long-range interaction, heat transfer, transportation, tribology, and microfl uidics. [2][3][4][5][6][7] One example is self-cleaning of dirts and pollutants from surfaces in environmental maintaining and microfabrication. [ 8 ] Maintaining SHO properties for a long lifetime is a major challenge, since SHO surfaces are easily contaminated by organic pollutants and stop functioning in practice.…”

Section: Introductionmentioning

confidence: 99%

Long‐Lived Multifunctional Superhydrophobic Heterostructure Via Molecular Self‐Supply

Huang

Zhu

et al. 2015

Adv Materials Inter

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encounters many diffi culties. Mimicking the lotus effect of plant leaves, SHO surfaces were found to be resulted from surface microstructures together with hydrophobic chemicals. Surface microstructures can be fabricated by various means including chemical vapor deposition (CVD), ion-beam and e-beam lithography. [17][18][19][20][21][22] However, these methods suffer from disadvantages such as calcinating at high temperatures, tedious and timeconsuming treatments, toxic chemicals, or processing with intricate instruments. For instance, Lau et al. deposited carbon nanotube forests on oxidized silicon by CVD at 650 °C with DC voltage bias of 600 V and then coated the forests with poly(tetrafl uoroethylene) to achieve SHO surfaces. [ 17 ] Deng et al. coated candle soot with silica at 600 °C for 24 h to fabricate superamphiphobic coatings. [ 18 ] Operating at temperatures ≥600 °C this approach is highly energy-intensive; it is also time-consuming costing days or longer. Lithography based on ion-beam and e-beam is also widely employed to fabricate microstructural surfaces. [ 19,20 ] However, this approach heavily relies on intricate ion-beam and e-beam instruments which are not easily accessible. Other problems include toxicity and unstability of raw materials applied. Hydrophobic chemicals and organic polymers such as perfl uorosilane, octadecyltricholorosilane, tetraethylorthosilicate, and others are commonly used to coat surface microstructures. [20][21][22] However, these chemicals are toxic, combustible, nonresistant to sunlight, unstable at high temperature (>260 °C), and/or diffi cult to maintain.Here we report a simple approach, based on self-supplying of low surface tension chemicals to nanoparticles, to fabricate SHO heterostructural surfaces featuring low temperature, rapid processing, with simple instruments and environment-friendly materials. Long-duration outdoor superhydrophobicity maintained for over a year is achieved. Furthermore, the surfaces made are endowed with extraordinary functions such as photocatalysis and transparency, enabling self-sustaining dust removal, and organic decomposition without poisoning. Besides, the heterostructures can be mounted fl exibly into ultrafi ne wettability patterns favoring water collection and microfl uidic applications. Results and DiscussionThe SHO surface in our experiment is a three-layer heterostructure, which can be fabricated on different types of substrates Superhydrophobic (SHO) surfaces have drawn great attention thanks to their theoretical signifi cance and myriad applications in industry and everyday life. Current approaches to fabricate such surfaces require calcinating at high temperatures, tedious and time-consuming treatments, toxic chemicals, and/ or processing with intricate instruments. Long-duration SHO surfaces are even more challenging due to material instability and easy contamination by organic pollutants in dry conditions. To overcome these diffi culties we design a simple approach via self-supplying of low surface tension chemicals to na...

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“…To improve the adhesion strength of coating, we construct superhydrophobic composite coating by using a hybrid of PDMS and STA-TiO 2 -FAS. PDMS facilitates replication of complex topographic patterns and exhibits a CA on a flat surface of 110 [31], it should be noted that PDMS itself has good adhesive force and satisfactory stability to the substrate because of the strong covalent bonding between the polymer and the Cu substrate, which is consistent with the general inertness of silicones contributing to the high stability. Many studies about the preparation of inorganic/PDMS composite coating have been published [32][33][34], the adhesion and hydrophobicity are greatly improved by the inorganic/organic polymer hybrid, is superior to the single inorganic coating.…”

Section: Resultsmentioning

confidence: 77%

Facile fabrication of superhydrophobic surfaces with corrosion resistance by nanocomposite coating of TiO2 and polydimethylsiloxane

Qing

Yang

Sun

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Completely Superhydrophobic PDMS Surfaces for Microfluidics

Cited by 143 publications

References 22 publications

The Functional Response of Mesenchymal Stem Cells to Electron‐Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity

The Functional Response of Mesenchymal Stem Cells to Electron‐Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity

Long‐Lived Multifunctional Superhydrophobic Heterostructure Via Molecular Self‐Supply

Facile fabrication of superhydrophobic surfaces with corrosion resistance by nanocomposite coating of TiO2 and polydimethylsiloxane

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