Complex Compounds of Glycyrrhizic Acid with Antimicrobial Drugs

Кондратенко, Р. М.; Балтина, Л. А.; Мустафина, С. Р.; Ismagilova, A. F.; Zarudii, F. S.; Davydova, V. A.; Bazekin, George; Suleimanova, G. F.; Толстиков, Г. А.

doi:10.1023/b:phac.0000008250.02124.d6

Cited by 20 publications

(8 citation statements)

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“…The percentage of survived animals with Pseudomonas aeruginosa, Proteus vulgaris, and E. coli infections reached 80% on GA: chloramphenicol administration but it was only 20-50% on treatment with free chloramphenicol. The complex was also shown to stimulate humoral and cell immune responses [59].…”

Section: Antimicrobial Drugsmentioning

confidence: 99%

Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

Душкин¹,

Толстикова²,

Хвостов³

et al. 2012

The Complex World of Polysaccharides

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Section: Antimicrobial Drugsmentioning

confidence: 99%

Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

Душкин¹,

Толстикова²,

Хвостов³

et al. 2012

The Complex World of Polysaccharides

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“…Nonetheless, the complex appeared to be more active than its individual components. [ 3 ] However, there is still no published data on the mass spectrometry (MS) investigation of molecular complexation of ChlA with GA so far. In this paper, the formation of glycoside molecular complexes with ChlA was studied by electrospray ionization (ESI) MS.…”

Section: Introductionmentioning

confidence: 99%

Study of molecular complexation of glycyrrhizic acid with chloramphenicol by electrospray ionization mass spectrometry

et al. 2015

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Context:Glycyrrhizic acid (GA) is a triterpene glycoside representing the main active component of licorice root extract obtained from plants of the Glycyrrhiza glabra L. and widely used as a complex-forming agent for the synthesis of new transport forms of the well-known drugs.Aims:For the first time, the complexation of GA with chloramphenicol antibiotic (ChlA) was investigated by electrospray ionization mass spectrometry (ESI MS).Subjects and Methods:ESI MS was utilized in order to determine the composition and evaluate the stability of complexes of the GA and ChlA. The validation of the complex formation was confirmed by ultraviolet/visible and infrared (IR) spectroscopy.Results:MS data confirmed the noncovalent interactions between chloramphenicol and GA. Formation of the host: guest complexes of GA and chloramphenicol with the ratio 1:1 and 2:1 were registered in the negative ion mode. Binding of GA and ChlA was accompanied by changes in absorbance and IR spectrum of ChlA indicating the complex formation of these compounds.Conclusions:The research results confirmed the considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA and the well-known drugs.

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“…GA is the glycoside of licuorice (Glycyrrhiza glabra) root and it's clathrates with nonsteroid anti-inflammatory drugs [7], prostaglandins [8], antiarrythmic allapinine (hydrobromide of diterpene alkaloid lappaconitine) [9,10], antidepressant prozac [11], antineoplastic drugs 5-fluorouracil, fluoroaphor, rubomicine [12], antimicrobial drugs such as laevomycetinum, sulphapyridosine (=microcidum), salazodimethoxin, sulginum, rezorcin [13] are pharmacologically promising.…”

Section: Introductionmentioning

confidence: 99%

Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

Tolstikov¹,

Хвостов²,

Лифшиц³

et al. 2011

LDDD

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The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacon's anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).

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Complex Compounds of Glycyrrhizic Acid with Antimicrobial Drugs

Cited by 20 publications

References 1 publication

Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

Study of molecular complexation of glycyrrhizic acid with chloramphenicol by electrospray ionization mass spectrometry

Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

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