Complex Hemangiomas of Infants and Children

Weber, Thomas; Connors, Robert H.; Tracy, Thomas F.; Bailey, Patrick V.

doi:10.1001/archsurg.1990.01410200081012

Cited by 77 publications

(19 citation statements)

References 13 publications

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“…There are several therapeutic options in the treatment of hemangioma with Kasabach-Merritt syndrome, which include platelet transfusion, corticosteroids, cryoprecipitate, heparin, ε-aminocaproic acid, dipyridamole, aspirin, cyclophosphamide, interferon, irradiation, local compression, surgical resection, laser therapy, cryosurgery and embolization [1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17]. The purposes of the treatment are to control coagulopathy and to eradicate or reduce the size of the lesions.…”

Section: Discussionmentioning

confidence: 99%

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Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

Komiyama

Nakajima

Kitano³

et al. 2000

Pediatr Neurosurg

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A 2-month-old girl with a huge cervicofacial hemangioma complicated by Kasabach-Merritt syndrome was presented. Two weeks corticosteroid treatment was ineffective, and deterioration of coagulation parameters and compromise of the airway and left vision due to huge hemangioma prompted use of endovascular treatment. Transfemoral arterial embolization using polyvinyl alcohol particles resulted in rapid clinical improvement. Endovascular treatment should be considered as an important therapeutic option for hemangioma complicated by Kasabach-Merritt syndrome.

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Section: Discussionmentioning

confidence: 99%

“…Interestingly, one therapeutic method does not always provide the same effects on the hemangioma even in the same individual [5, 7, 10, 11]. Thus, the treatment should be individualized, and a plan of sequential treatment progressing from simple measures to more complex therapy is followed [3, 16]. …”

Section: Discussionmentioning

confidence: 99%

Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

Komiyama

Nakajima

Kitano³

et al. 2000

Pediatr Neurosurg

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“…Cerca de 30 a 70% dos pacientes beneficiam-se dessa modalidade terapêutica 2,3 , geralmente empregada em altas doses, o que aumenta o risco dos efeitos colaterais [2][3][4] .…”

Section: -Silva Cmr Et Aliiunclassified

“…A radioterapia possui importante potencial oncogênico, a ressecção cirúrgica nem sempre é possível em lesões volumosas, a crioterapia é restrita às lesões precoces e de pequenas dimensões. A embolização é de difícil realização e exige pessoal treinado enquanto a ciclofosfamida deve ter sua relação risco/benefício cuidadosamente avaliada 4,6 .…”

Section: -Silva Cmr Et Aliiunclassified

“…Esses hemangiomas estão associados a uma taxa de mortalidade de 20 a 50 %, a menos que sejam tratados de forma agressiva 1 . Tratamentos com corticosteróides [2][3][4][5][6] , embolização arterial 4,6 , cirurgia 4 , crioterapia 6 , radioterapia 6 , quimioterapia 6 , e laser [6][7][8] têm sido usados com resultados variáveis. O interferon alfa (INF-a) tem-se mostrado efetivo em casos selecionados 1,[5][6][7][9][10][11][12] .…”

Section: Introductionunclassified

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Giant hemangioma treated with interferon alpha-2a

Silva

Mb²,

Fernandes³

et al. 1997

J Pediatr (Rio J)

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ResumoObjetivo: Os autores descrevem um caso de hemangioma gigante na infância tratado com interferon alfa-2a e fazem a revisão da literatura pertinente ao uso dessa droga e de outras modalidades terapêuticas nesse tipo de lesão vascular.Métodos: Uma criança de sete meses de idade, portadora de hemangioma gigante complicado com anemia persistente, hemorragias e infecções de repetição, foi tratada com interferon alfa-2a. A dose utilizada foi de 3 milhões de unidades/m 2 /dia, por via subcutânea, durante um período de nove meses.Resultados: A paciente apresentou uma excelente resposta ao tratamento instituído, com regressão de cerca de 90% da lesão, controle da anemia, infecções e hemorragias, e retomada do crescimento. Não foram detectados efeitos colaterais.Conclusão: O interferon alfa-2a pode ser considerado uma boa opção terapêutica em casos selecionados de hemangioma na infân-cia. J. pediatr. (Rio J.). 1997; 73(4):277-280:hemangioma, interferon, interferon alfa, terapêutica. AbstractObjetive: The authors describe a case of giant hemangioma treated with interferon alpha-2a and review the role of this drug and other therapeutic modalities in the management of vascular lesions.Methods: A seven month-old child with giant hemangioma and persistent bleeding, anemia and repeated infections was treated with interferon alpha-2a. The drug was administered at the dosage of 3 million units/m 2 /day, subcutaneously, for nine months.Results: Response to treatment was considered excellent, with regression of 90% of the lesion, control of bleeding, infection and anemia, and catch-up growth. No untoward effects were observed.Conclusion: Interferon alpha-2a should be considered as a valid therapeutic option in selected cases of hemangioma in children.

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An Update on the Treatment of Hemangiomas in Children With Interferon Alfa-2a

Greinwald¹,

Burke²,

Bonthius³

et al. 1999

Arch Otolaryngol Head Neck Surg

136

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In pediatric patients with massive or life-threatening hemangiomas, interferon alfa-2a therapy is an effective treatment option. However, neurological evaluation before and during therapy with interferon alfa-2a should be performed owing to a significant incidence of neurological abnormalities (28%). Although all children with neurological findings demonstrated neurological recovery after discontinuation of therapy, we have changed our protocol and now more gradually increase the dosage of interferon alfa-2a up to 3 million U/m2 per day. The effect of this modification on the development of neurological abnormalities has not yet been determined.

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Complex Hemangiomas of Infants and Children

Cited by 77 publications

References 13 publications

Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

Giant hemangioma treated with interferon alpha-2a

An Update on the Treatment of Hemangiomas in Children With Interferon Alfa-2a

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