Complex interactions of circadian rhythms, eating behaviors, and the gastrointestinal microbiota and their potential impact on health

Kaczmarek, Jennifer; Thompson, Sharon V.; Holscher, Hannah D.

doi:10.1093/nutrit/nux036

Cited by 87 publications

(57 citation statements)

References 61 publications

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“…feeding patterns) and antibiotic exposure regulates the evolution of drug resistance. We can nevertheless draw some insight from emerging research into the effects of feeding patterns, independent of nutritional composition, on gut microbiome stability [50][51][52] .…”

Section: Coexistence and Resistance In Dynamic Environmentsmentioning

confidence: 99%

Antibiotics in microbial communities: an ecological frame of resistance

Letten

Hall²,

Levine

2020

Preprint

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There is growing awareness that our ability to tackle antibiotic resistance is limited by a lack of mechanistic understanding of the communities in which resistant microbes are embedded. The widespread coexistence of resistant and sensitive bacteria in microbial systems presents an especially frustrating paradox. Recent advances in ecological coexistence theory offer a powerful framework to probe the mechanisms regulating intra-and inter-specific coexistence, but the significance of this body of theory to the problem of antimicrobial resistance has been largely overlooked. In this Perspectives article, we draw on emerging ecological theory to illustrate how changes in both competitive ability and niche overlap are critical for understanding costs of resistance and the persistence of pathogens in microbial systems. We then show how trade-offs in resource acquisition strategies can have counter-intuitive consequences for the coexistence of resistant and susceptible genotypes in variable environments. These insights highlight numerous opportunities for innovative experimental and theoretical research into antibiotic resistance in the microbiome.

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Section: Coexistence and Resistance In Dynamic Environmentsmentioning

confidence: 99%

Antibiotics in microbial communities: an ecological frame of resistance

Letten

Hall²,

Levine

2020

Preprint

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“…Interestingly, chrononutrition has become extremely important as modulator of microbiota, since disruption of circadian rhythms can increase the risk of disease [10]. It is known that microbiome is affected by what is eaten but also by when food is consumed [11]. Time of eating has been reported to restore circadian rhythms affecting bacterial communities and its function [10][11][12].…”

Section: Modulation Of the Gut Microbiota Profilementioning

confidence: 99%

“…It is known that microbiome is affected by what is eaten but also by when food is consumed [11]. Time of eating has been reported to restore circadian rhythms affecting bacterial communities and its function [10][11][12]. In fact, time-restricted feeding (TRF), an eating pattern in which food intake is restricted to a time window which can oscillates between 8 and 12 h [13,14], is able to restore the cycling of the microbiota [11].…”

Section: Modulation Of the Gut Microbiota Profilementioning

confidence: 99%

“…Time of eating has been reported to restore circadian rhythms affecting bacterial communities and its function [10][11][12]. In fact, time-restricted feeding (TRF), an eating pattern in which food intake is restricted to a time window which can oscillates between 8 and 12 h [13,14], is able to restore the cycling of the microbiota [11]. Therefore, restoring circadian rhythms, including microbiota rhythm, may also contribute to optimize individual's physiology and decrease their risk of disease [10].…”

Section: Modulation Of the Gut Microbiota Profilementioning

confidence: 99%

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Keto microbiota: A powerful contributor to host disease recovery

Cabrera-Mulero

Tinahones

Bandera

et al. 2019

Rev Endocr Metab Disord

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Gut microbiota (GM) is a key contributor to host metabolism and physiology. Data generated on comparing diseased and healthy subjects have reported changes in the GM profile between both health states, suggesting certain bacterial composition could be involved in pathogenesis. Moreover, studies reported that reshaping of GM could contribute actively to disease recovery. Interestingly, ketogenic diets (KD) have emerged recently as new economic dietotherapeutic strategy to combat a myriad of diseases (refractory epilepsy, obesity, cancer, neurodegenerative diseases…). KD, understood in a broad sense, refers to whatever dietetic approximation, which causes physiological ketosis. Therefore, high fat-low carbs diets, fasting periods or caloric restriction constitute different strategies to produce an increase of main ketones bodies, acetoacetate and β-hydroxybutyrate, in blood. Involved biological mechanisms in ketotherapeutic effects are still to be unravelled. However, it has been pointed out that GM remodelling by KD, from now on "keto microbiota", may play a crucial role in patient response to KD treatment. In fact, germfree animals were resistant to ketotherapeutic effects; reinforcing keto microbiota may be a powerful contributor to host disease recovery. In this review, we will comment the influence of gut microbiota on host, as well as, therapeutic potential of ketogenic diets and keto microbiota to restore health status. Current progress and limitations will be argued too. In spite of few studies have defined applicability and mechanisms of KD, in the light of results, keto microbiota might be a new useful therapeutic agent.

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“…• Findings relating the gastrointestinal microbiota to disease states may help combat this prevalent issue (2). • Relations between meal pattern and the microbiota remain to be elucidated (3).…”

Section: Table 2 Associations Of Metabolite Concentrations and Bactementioning

confidence: 99%