Complex level alterations of the 2f1–f2 distortion product due to hypoxia

Kisser, Ulrich; Becker, Sven; Feddersen, Berend; Fischer, Rainald; Fesl, Gunther; Haegler, Katrin; Grashey, Rupert; Adderson-Kisser, Christine; Mees, K.; Olzowy, Bernhard

doi:10.1016/j.anl.2013.07.009

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…Similar results were reported describing the difference when comparing cases with and without hypoxia (18)(19)(20)(21) . In a study that investigated the effects of hypoxia in the inner ear in adults through DPOAEs, the authors (18) observed a significant decrease in the amplitude of DPOAE during hypoxia in 5 of the 16 people tested. The destabilization of the level of DPOAE with considerable fluctuations during hypoxia was observed in nine individuals.…”

Section: Discussionsupporting

confidence: 86%

“…One study that explored the long-term effects of hypoxia in the hearing of animals using Auditory Brainstem Responses (ABRs) (18) and another study (20) that examined the DPOAEs in children with a history of hypoxia also showed results similar to this study. While hearing, evaluation methods used were different and different parts of the auditory pathway have been examined; the similarity of the results suggests that the effects of hypoxia can occur both at the level of the outer hair cells and of the brainstem.…”

Section: Discussionsupporting

confidence: 66%

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Emissões otoacústicas em recém-nascidos com hipóxia perinatal leve e moderada

Leite¹,

Silva²,

Buzo³

2016

CoDAS

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Introduction Severe neonatal hypoxia (as evidenced by the Apgar value) is currently considered the only risk for hearing loss. Hypoxia is one of the most common causes of injury and cell death. The deprivation of oxygen in mild or moderate cases of hypoxia, although smaller, occurs and could cause damage to the auditory system. Objective To investigate the amplitude of otoacoustic emissions in neonates at term with mild to moderate hypoxia and no risk for hearing loss. Methods We evaluated 37 newborns, divided into two groups: a control group of 25 newborns without hypoxia and a study group of 12 newborns with mild to moderate hypoxia. TEOAE and DPOAE were investigated in both groups. Results The differences between groups were statistically significant in the amplitude of DPOAE at the frequencies of 1000, 2800, 4000 and 6000 Hz. In TEOAE, statistically significant differences were found in all tested frequency bands. OAE of the study group were lower than those in the control group. Conclusion Although the occurrence of mild and moderate neonatal hypoxia is not considered a risk factor for hearing loss, deprivation of minimum oxygen during neonatal hypoxia seems to interfere in the functioning of the outer hair cells and, consequently, alter the response level of otoacoustic emissions. Thus, hese children need longitudinal follow-up in order to identify the possible impact of these results on language acquisition and future academic performance.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 66%

Emissões otoacústicas em recém-nascidos com hipóxia perinatal leve e moderada

Leite¹,

Silva²,

Buzo³

2016

CoDAS

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“…The most significant effect of hypoxia in ABR is I-V prolongation in IPL [3,17]. A change in ABR waves occurs when the pO 2 value reaches the prehypoxic value after reoxygenation, not during hypoxia.…”

Section: Discussionmentioning

confidence: 98%

“…In the first 15 min following cochlear ischemia, swelling and deterioration occurred in the external shaky hair cells. When the external shaky hair cells were examined more closely (ultrastructurally), it was observed that these cells had swelling and distortion in the mitochondria, endoplasmic reticulum, and nuclei [15,17]. Ischemic symptoms caused by acute hypoxia may not improve during the reperfusion period.…”

Section: Discussionmentioning

confidence: 99%

The effect of hypoxia on hearing function

Yilmaz¹,

Saka²,

Arslan³

et al. 2019

Turk J Med Sci

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Background/aim: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD). Materials and methods: The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO 2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group. Results: A statistically significant difference was found between the two groups for distortion-product otoacoustic emission (DPOAE) (P < 0.001). The COPD group was divided into two groups according to pO 2 levels (pO 2 ≤ 70 and pO 2 > 70) in order to find a critical pO 2 level which might cause significant change at a certain audiological extent. Conclusion: Hypoxia causes long-term decline in hearing thresholds, deterioration of DPOAE results, and prolongation of I-V interpeak latency in auditory brainstem response. However, the critical oxygen level that disrupts hearing function could not be determined.

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“…Rebillard and Lavigne-Rebillard [9] created an artificial hypoxic environment by letting guinea pigs breathe 10% oxygen, and they showed a decrease in DPOAE levels in the hypoxic environment. The DPOAE values did not deteriorate in a mildly hypoxic environment suggesting that the cochlea had a SaO2 value in which the cochlea was operating normally [12,13]. Therefore, the cochlea has an autoregulatory mechanism that provides adequate blood flow in case of mild hypoxia.…”

Section: Discussionmentioning

confidence: 95%

Effects of acute hypoxia on auditory pathway of Wistar albino rats

et al. 2020

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Background/aim: Ischemia is insufficient blood flow to provide adequate oxygenation. In the present study, we aimed to show whether acute hypoxia has a critical oxygen value that may lead to the deterioration of cochlear function.Materials and methods: Under general anesthesia, prehypoxic signal-to-noise ratios were determined by distortion product otoacoustic emissions (DPOAE). The oxygen saturation (SaO2) values of rats were monitored with an oxygen saturation probe. Rats were injected with an extra dose of anesthetic agent, and SaO2 was reduced. DPOAE values in SaO2 100–90, 90–80, 80–70, and 70–60 posthypoxic values were measured and compared statistically with prehypoxic values.Results: At 3000 and 4000 Hz, SaO2 70–60 values measured after the hypoxia were observed to be statistically significantly lower than the values measured before the hypoxia. At 6000 and 8000 Hz, SaO2 80–70 and 70–60 values measured after the hypoxia were observed to be statistically significantly lower than the values measured before the hypoxia. At 10,000 Hz, all of the values measured after the hypoxia were observed to be statistically significantly lower than the values obtained before the hypoxia.Conclusion: Many studies have been conducted on the effects of hypoxia on the inner ear. It remains unclear how fluctuations in DPOAE levels affect hearing in clinical trials when the SaO2 starts to decrease. Although hypoxia has been implicated in the etiology of sudden hearing loss and tinnitus, the effects of acute hypoxia on the cochlea are still uncertain. Further studies are needed on this subject.

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Complex level alterations of the 2f1–f2 distortion product due to hypoxia

Cited by 9 publications

References 11 publications

Emissões otoacústicas em recém-nascidos com hipóxia perinatal leve e moderada

Emissões otoacústicas em recém-nascidos com hipóxia perinatal leve e moderada

The effect of hypoxia on hearing function

Effects of acute hypoxia on auditory pathway of Wistar albino rats

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