Complex supplementation containing mineral bishofit (MgCl2·6H2O) solution and pyridoxine hydrochloride normalises ethanol-induced magnesium depletion and corrects some behavioural disturbances of animals during chronic alcoholisation

Iezhitsa, Igor Nikolayevich; Onishchenko, N. V.; Churbakova, N. V.; Parshev, V V; Петров, В. И.

doi:10.1016/s0924-977x(02)80741-6

European Neuropsychopharmacology

2002

DOI: 10.1016/s0924-977x(02)80741-6

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Complex supplementation containing mineral bishofit (MgCl2·6H2O) solution and pyridoxine hydrochloride normalises ethanol-induced magnesium depletion and corrects some behavioural disturbances of animals during chronic alcoholisation

Igor Nikolayevich Iezhitsa¹,

N. V. Onishchenko²,

N. V. Churbakova³

et al.

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“…Spasov et al [21] showed that a magnesiumdeficient diet in rats is associated with depressionlike and anxiety behavior and that Mg-l-aspartate and MgCl 2 × 6H 2 O in combination with pirydoxine led to a correction of behavioral disturbances in those rats. Iezhitsa et al [22] showed that magnesium administration associated with vitamin B6 corrected depression-like behavioral disturbances in rats with chronic alcoholism. Some experimental studies have shown that concomitant administration of magnesium increased the effect of imipramine on immobility in stress-induced depression-like behavior in forced swim tests on mice [23].…”

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confidence: 99%

Magnesium in major depression

Nechifor¹

2009

Magnesium Research

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There are contradictory data regarding the levels of magnesium in patients with major depression (MD) and how antidepressants influence their concentration. Our results show erythrocyte magnesium in patients with MD (44.39 ± 2.7 mg/L vs 59.1 ± 3.2 mg/L in control group, p < 0.05) and only in patients with severe MD (Hamilton score > 23) was a moderate decrease in plasmatic magnesium observed (17.7 ± 1.5 mg/L vs 22.9 ± 3.3 mg/L in control group). Therapy with antidepressants from different groups and with different mechanisms of action, such as amytriptiline (25 mg x 3/day per os, 4 weeks) and sertraline (50 mg x 3/day per os, 4 weeks) leads to a significant increase of magnesium concentration in erythrocytes (57.6 ± 4.5 mg/L after amytriptiline, respectively 56.9 ± 3.2 mg/L after sertraline, p < 0.05 vs before therapy). At the same time, in patients with MD, plasmatic levels of zinc were significantly decreased before therapy and increased after treatment with amytriptiline and sertraline (0.68 ± 0.09 mg/L before treatment vs 0.9 ± 0.07 after amytriptiline). There is a positive correlation between concentrations of magnesium in erythrocytes and the clinical evolution of patients with MD. We consider that increasing intracellular concentration is a component of the antidepressant mechanism of sertraline and amytriptiline and maybe of other antidepressants. Anhedonia and autolytic tendencies are important elements of MD symptomatology. We tested the influence of MgCl 2 0.2 mM/kg/day on a reward system using conditioned place preference (Panlab) in rats. Our data show a moderate stimulation of the reward system by magnesium (290.6 ± 27 s time spent in a conditioned compartment before magnesium treatment and 363.3 ± 16 s after magnesium treatment) that reflects a stimulation of the reward system (RS). We consider that a magnesiuminduced stimulation of the RS is an important issue for treating anhedonia in patients with MD. An increase of intracellular magnesium may be part of the mechanism of action of antidepressants.

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Magnesium in major depression

Nechifor¹

2009

Magnesium Research

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An eco-friendly and stable capillary zone electrophoresis method for the analysis of metadoxine based on accurate molar response factor obtained from crystal

Zhao,

Zuo,

Liu

et al. 2025

Sustainable Chemistry and Pharmacy

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Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine,d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan

Iezhitsa

Spasov

Kharitonova

et al. 2011

Nutritional Neuroscience

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Complex supplementation containing mineral bishofit (MgCl2·6H2O) solution and pyridoxine hydrochloride normalises ethanol-induced magnesium depletion and corrects some behavioural disturbances of animals during chronic alcoholisation

Cited by 3 publications

References 0 publications

Magnesium in major depression

Magnesium in major depression

An eco-friendly and stable capillary zone electrophoresis method for the analysis of metadoxine based on accurate molar response factor obtained from crystal

Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine,d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan

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