The neurodegenerative disorders (NDDs) are characterized by protein and other pathologies which can be reflected in biofluids. • The use of cerebrospinal fluid (CSF) analysis and molecular imaging has been critical in stratifying populations based on diagnosis and underlying pathology, but are limited as population screening tools. • Advances in ultra-sensitive immunoassay measurement of amyloid-β, neurofilament light and tau, as well as mass spectrometry-based methods for amyloid, have demonstrated that a blood-based screening tool for Alzheimer's disease (AD) is a realistic and plausible possibility. • This evidence is now indicating that such blood biomarkers could be important for other common NDDs (e.g, LBD & FTD).