Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

Цебрикова, Г. С.; Barsamian, R. T.; ́ev, V. P. Solov; Kudryashova, Z. A.; Баулин, В. Е.; Wang, Y. J.; Tsivadze, A. Yu.

doi:10.1007/s11172-018-2352-8

Cited by 5 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Potentiometric titration with the aim of determining the protonation constants of H 3 L 1 acid and the stability constants of its complexes with copper(II) perchlorate was performed according to the method [41], using an OP-300 Radelkis potentiometer. To study the complex formation, chemically-pure grade copper(II) perchlorate hexahydrate was used.…”

Section: Methodsmentioning

confidence: 99%

“…The average values of the protonation constants of H 3 L 1 acid were determined from eight estimates of the constants obtained using two best titrations and four calculation algorithms. In all calculations of the constants, Hamilton's R-factor (HRF) and the determination coefficient (R 2 det ) were used as criteria for the agreement of the assumed set of equilibrium reactions in solution with experimental data [41]. For H 3 L 1 acid, the HRF factor ranged from 0.62 to 1.11%, and the R 2 det coefficient ranged from 0.9990 to 0.9997.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Complexation Properties of 2-Hydroxy-5-methoxyphenylphosphonic Acid (H3L1). Crystal Structure of the [Cu(H2L1)2(Н2О)2] Complex

et al. 2021

Self Cite

View full text Add to dashboard Cite

2-Hydroxy-5-methoxyphenylphosphonic acid (H3L1) and the complex [Cu(H2L1)2(H2O)2] were synthesized and characterized by IR spectroscopy, thermogravimetry, and X-ray diffraction analysis. The polyhedron of the copper atom is an axially elongated square bipyramid with oxygen atoms of phenolic and of monodeprotonated phosphonic groups at the base and oxygen atoms of water molecules at the vertices. The protonation constants of the H3L1 acid and the stability constants of its Cu2+ complexes in water were determined by potentiometric titration. The protonation constants of the acid in water are significantly influenced by the intramolecular hydrogen bond and the methoxy group. The H3L1 acid forms complexes CuL‒ and CuL24‒ with Cu2+ in water.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Synthesis and Complexation Properties of 2-Hydroxy-5-methoxyphenylphosphonic Acid (H3L1). Crystal Structure of the [Cu(H2L1)2(Н2О)2] Complex

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The potentiometric titration technique using the OP-300 Radelkis potentiometer was described earlier [35]. Solutions of 8 and 9 were titrated with a standard 0.1 МNaOH solution at 298 ± 0.1 K and ionic strength of I = 0.1 M KCl.…”

Section: Stability Constant Measurements and Calculationsmentioning

confidence: 99%

“…The Hamilton's R-factor (HRF) and the squared determination coefficient (R 2 det ) were used as the agreement criteria of the proposed set of equilibrium reactions and calculated constants with the experimental data [35]. Depending on the experiment and the program algorithm, HRF was 0.30-0.96% (8), 0.46-0.92% (9) at the calculations of protonation constants, 0.99-1.50% (8 + Ga 3+ ), and 1.41-3.18% (9 + Ga 3+ ) at the calculations of stability constants of the Ga 3+ complexes.…”

Section: Stability Constant Measurements and Calculationsmentioning

confidence: 99%

Synthesis, Complexation Properties, and Evaluation of New Aminodiphosphonic Acids as Vector Molecules for 68Ga Radiopharmaceuticals

et al. 2021

View full text Add to dashboard Cite

Two new aminodiphosphonic acids derived from salicylic acid and its phosphonic analogue were prepared through a simple and efficient synthesis. 2-[(2-Amino-2,2-diphosphono)ethyloxy]-benzoic acid 8 and 2-[(2-amino-2,2-diphosphono)ethyloxy]-5-ethyl-phenylphosphonic acid 9 were evaluated for their applicability as 68Ga binding bone-seeking agents. Protonation constants of 8 and 9 and stability constants of the Ga3+ complexes with 8 and 9 in water were determined. The stability constant of Ga3+ complex with fully phosphorylated acid 9 (logKGaL = 31.92 ± 0.32) significantly exceeds stability constant of Ga3+ complex with 8 (logKGaL = 26.63 ± 0.24). Ligands 8 and 9 are as effective for Ga3+ cation binding as ethylenediamine-N,N’-diacetic-N,N’-bis(methy1enephosphonic) acid and ethylenediamine-N,N,N’,N’-tetrakis(methylenephosphonic) acid, respectively. The labelling process and stability of [68Ga]Ga-8 and [68Ga]Ga-9 were studied. Both 8 and 9 readily form 68Ga-complexes stable to ten-fold dilution with saline. However, in fetal bovine serum, only [68Ga]Ga-9 was stable enough to be subject to biological evaluation. It was injected into rats with bone pathology and aseptic inflammation of soft tissues. For [68Ga]Ga-9 in animals with a bone pathology model in 60 and 120 min after injection, a slight accumulation in the pathology site, stable blood percentage level, and moderate accumulation in the liver were observed. For animals with an aseptic inflammation, the accumulation of [68Ga]Ga-9 in the pathology site was higher than that in animals with bone pathology. Moreover, the accumulation of [68Ga]Ga-9 in inflammation sites was more stable than that for [68Ga]Ga-citrate. The percentage of [68Ga]Ga-9 in the blood decreased from 3.1% ID/g (60 min) to 1.5% ID/g (120 min). Accumulation in the liver was comparable to that obtained for [68Ga]Ga-citrate.

show abstract

(2-Hydroxyphenyl)phosphonic acid: complexation with the copper(ii) cation, toxicity, and accumulation in HeLa cells

et al. 2022

View full text Add to dashboard Cite

Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

Cited by 5 publications

References 19 publications

Synthesis and Complexation Properties of 2-Hydroxy-5-methoxyphenylphosphonic Acid (H3L1). Crystal Structure of the [Cu(H2L1)2(Н2О)2] Complex

Synthesis and Complexation Properties of 2-Hydroxy-5-methoxyphenylphosphonic Acid (H3L1). Crystal Structure of the [Cu(H2L1)2(Н2О)2] Complex

Synthesis, Complexation Properties, and Evaluation of New Aminodiphosphonic Acids as Vector Molecules for 68Ga Radiopharmaceuticals

(2-Hydroxyphenyl)phosphonic acid: complexation with the copper(ii) cation, toxicity, and accumulation in HeLa cells

Contact Info

Product

Resources

About