Complexation of norfloxacin with DNA in the presence of caffeine

Evstigneev, Maxim P.; Rybakova, Katja N.; Davies, David B.

doi:10.1016/j.bpc.2005.12.003

Cited by 39 publications

(28 citation statements)

References 30 publications

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“…It has been reported previously that CAF and other MTX form stacking aggregates with aromatic dyes: acridine orange [82][83][84], ethidium bromide [20,81,85], 4 ,6-diamidino-2-phenylindole (DAPI) [81], methylene blue [86], anticancer drugs: doxorubicin, mitoxantrone, and daunomycin [17,24,81,87], antibacterial agent norfloxacin [88], vitamin B 2 derivative flavinmononucleotide [87], neurotoxins [36,89], and aromatic mutagens [22,35]. Some of these reports reveal in vivo effects of observed heterocomplexation, indicating that molecular complex formation between aromatic compounds can be relevant in biological systems [22,35,36,89].…”

Section: Heterocomplexation Of Mtx With Other Aromatic Ligandsmentioning

confidence: 99%

“…It was demonstrated that CAF and other MTX can inhibit DNA binding or even induce deintercalation of aromatic ligands from DNA [20,21,84,88]. It is still discussed whether this effect results barely from the decrease in ligand availability due to its interception by MTX or can be also contributed to the reduction of binding sites on DNA available for ligands caused by MTX intercalation.…”

Section: Heterocomplexation Of Mtx With Other Aromatic Ligandsmentioning

confidence: 99%

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Heterocyclic Aromatic Amines Heterocomplexation with Biologically Active Aromatic Compounds and Its Possible Role in Chemoprevention

2013

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Food-borne heterocyclic aromatic amines (HCAs) are known mutagens and carcinogens present especially in Western population diet, which contains large amount of meat and its products. HCAs are capable of interacting with DNA directly through the formation of covalent adducts, however this process requires biological activation in liver, mainly by cytochrome P450 enzymes. This process may produce mutations and in consequence may contribute to the development of cancer. However, there are many studies showing that several biologically active aromatic compounds (BACs) may protect against genotoxic effects of HCAs. Direct interactions and noncovalent heterocomplexes formation may be one of the most important mechanisms of such protection. This work describes several BACs present in human diet, which are capable of molecular complexes formation with HCAs and protect cells as well as whole organisms against HCAs action.

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Section: Heterocomplexation Of Mtx With Other Aromatic Ligandsmentioning

confidence: 99%

Section: Heterocomplexation Of Mtx With Other Aromatic Ligandsmentioning

confidence: 99%

Heterocyclic Aromatic Amines Heterocomplexation with Biologically Active Aromatic Compounds and Its Possible Role in Chemoprevention

2013

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“…A method has been suggested to analyse the 'interceptor' and 'protector' mechanisms simultaneously in recent reports on the CAF-Antibiotic [44,64] and Vitamin-Antibiotic [50] systems. In the present work that analysis is generalised for the group of aromatic molecules, which exert their biological effect via complexation with DNA.…”

Section: Introductionmentioning

confidence: 99%

Quantitation of the molecular mechanisms of biological synergism in a mixture of DNA-acting aromatic drugs

Evstigneev¹,

Лантушенко²,

Evstigneev³

et al. 2008

Biophysical Chemistry

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“…Hetero-association in Drug-xanthine systems has been extensively studied by NMR, UV-vis, Fluorescence spectroscopies, titration microcalorimetry, partitioning in waterorganic mixture, molecular modelling and other techniques for the following aromatic drugs: daunomycin (DAU) [127,[133][134][135][136], doxorubicin (DOX) [33,42,127,[137][138][139], actinomycin D (AMD) and its derivatives [133,[140][141][142][143], benzene and its derivatives [122,144], novantrone/mitoxantrone (NOV) [42, 127, 135-137, 145, 146], nogalamycin (NOG) [138], norfloxacin (NOR) [135,136,147], camptothecins [139,148,149], quinoxaline [84], chloroquine [84], DAPI [150], phenothiazines [121,151,152], riboflavin [135,[153][154][155], porphyrins [156,157], acridine mutagens [53,54,124,125,[133][134]…”

Section: Drug-xanthine Systemmentioning

confidence: 99%

Hetero-association of aromatic molecules in aqueous solution

Evstigneev

2014

International Reviews in Physical Chemistry

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Knowledge of the physical chemistry of small molecules complexation (the hetero-association) in aqueous solution is increasingly important in view of the rapidly emerging branch of supramolecular chemistry dealing with the formation of heterogeneous polymeric structures having specific functional roles. In this paper, the 50-year history of scientific studies of hetero-association of heterocyclic aromatic molecules in aqueous solution has been reviewed. Some important correlations of structural and thermodynamic parameters of complexation have been reported based on large data-set of hetero-association parameters accumulated to date. The fundamental problem of 'energetic composition' of π-stacking is extensively discussed. The review has shown that there are some gaps in our understanding of heteroassociation, which provides a challenge for further studies in this area.

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Complexation of norfloxacin with DNA in the presence of caffeine

Cited by 39 publications

References 30 publications

Heterocyclic Aromatic Amines Heterocomplexation with Biologically Active Aromatic Compounds and Its Possible Role in Chemoprevention

Heterocyclic Aromatic Amines Heterocomplexation with Biologically Active Aromatic Compounds and Its Possible Role in Chemoprevention

Quantitation of the molecular mechanisms of biological synergism in a mixture of DNA-acting aromatic drugs

Hetero-association of aromatic molecules in aqueous solution

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