Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line

Al-Omar, Anouar; Abdou, Souad; Robertis, L. de; Marsura, Alain; Finance, C.

doi:10.1016/s0960-894x(99)00150-x

Cited by 40 publications

(14 citation statements)

References 9 publications

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“…As for DOX, the inclusion complex formation was investigated by fluorescence emission measurements of DOX in the presence of β‐CD‐ g ‐(PEG‐ v ‐PNIPAAm) 7 at various concentrations. As shown in Figure D, with increasing amount of β‐CD‐ g ‐(PEG‐ v ‐PNIPAAm) 7 , the typical fluorescence intensity of DOX at 600 nm decreases sharply, indicating the enhanced host–guest interaction between the two molecules, as reported previously …”

Section: Resultssupporting

confidence: 83%

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Fan

Cheng

Wang

et al. 2017

Adv Healthcare Materials

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Pump mediated drug efflux is the key reason to result in the failure of chemotherapy. Herein, a novel star polymer β-CD-v-(PEG-β-PNIPAAm) consisting of a β-CD core, grafted with thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(ethylene glycol) (PEG) in the multiple "V"-shaped arms is designed and further fabricated into supramolecular nanocarriers for drug resistant cancer therapy. The star polymer could encapsulate chemotherapeutics between β-cyclodextrin and anti-cancer drug via inclusion complex (IC). Furthermore, the temperature induced chain association of PNIPAAm segments facilitated the IC to form supramolecular nanoparticles at 37 °C, whereas the presence of PEG impart great stability to the self-assemblies. When incubated with MDR-1 membrane pump regulated drug resistant tumor cells, much higher and faster cellular uptake of the supramolecular nanoparticles were detected, and the enhanced intracellular retention of drugs could lead to significant inhibition of cell growth. Further in vivo evaluation showed high therapeutic efficacy in suppressing drug resistant tumor growth without a significant impact on the normal functions of main organs. This work signifies thermo-responsive supramolecular chemotherapy is promising in combating pump mediated drug resistance in both in vitro and in vivo models, which may be encouraging for the advanced drug delivery platform design to overcome drug resistant cancer.

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Section: Resultssupporting

confidence: 83%

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Fan

Cheng

Wang

et al. 2017

Adv Healthcare Materials

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“…1 However, Dox is light sensitive due to its chemical structure ( Figure 1) of a tetracyclic anthraquinoid aglycone. [2][3][4] To improve the solubility and stability of Dox in aqueous solution, hydroxypropyl-β-cyclodextrin (HP-β-CD) is selected to be a carrier of Dox because of its improved complexing ability, greater water solubility, 5 and lower toxicity. 3,6,7 Recently, HP-β-CD has been proved to be a proper excipient for increasing solubility or stability of 13-cis-RA 8 and Ropivacaine 9 by forming the inclusion complexes.…”

Section: Introductionmentioning

confidence: 99%

Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl‐β‐cyclodextrin

Peng¹,

Liu²,

Zhang³

et al. 2010

Chin. J. Chem.

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The photodegradation of doxorubicin (Dox) in the presence of hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied; the degradation rate constant in the presence of HP-β-CD estimated by Lineweaver-Burk analysis was approximately three times lower than that of free Dox aqueous solution, which shows that HP-β-CD can enhance the photostability of doxorubicin aqueous solution. The enhancement may be attributed to the inclusion interaction between HP-β-CD and doxorubicin. The characterization of FTIR, DSC, XRD and fluorescence titration indicates that 1∶1 inclusion complex is formed between HP-β-CD and doxorubicin.

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“…Improvement of stability for several drugs was carried out upon complexation with cyclodextrins (CDs) [8,9]. The ability to form an inclusion complex with a large variety of non-polar and hydrophobic molecules is the most interesting property of CDs [10,11]. Complexation with the CDs increased aqueous solubility of a drug [12,13] and may be involved in many other physico-chemical properties [14].…”

Section: Introductionmentioning

confidence: 99%

2-Hydroxypropyl β-Cyclodextrin: A New Tool for the Improvement of Chemical Stability of Tiagabine HCl

Sughir¹,

Lahiani-Skiba²,

Oulyadi³

et al. 2009

LDDD

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The aim of this paper was to describe the use of a 2-hydroxypropyl beta-cyclodextrin (2-HP CD) as a tool to improve the chemical stability of tiagabine hydrochloride (TGB). HPLC method was used to quantify TGB. The correlation coefficient of the linearity (r 2 ) of HPLC method was more than 0.999 whilst the limit of detection and the limit of quantification of TGB were 0.6494 g ml -1 and 1.765 g ml -1 respectively. The effect of 2-HP CD on the chemical stability of TGB was compared with -tocopherol and ascorbic acid, the most recognized antioxidants used to enhance the stability of TGB. The stability was expressed by (% w/w) of the total related substances (TRS) of TGB. When TGB was exposed for 24 h to 50°C, the TRS were 3.264% (SD ±0.077) and 3.125% (SD ±0.053) in the presence of -tocopherol and ascorbic acid, respectively. The TRS of TGB complexed with 2-HP CD was 2.142% (SD ±0.045). This study demonstrates that 2-HP CD exhibits an obvious enhancement of TGB chemical stability with a different mechanism compared with the usual antioxidants.

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Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line

Cited by 40 publications

References 9 publications

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl‐β‐cyclodextrin

2-Hydroxypropyl β-Cyclodextrin: A New Tool for the Improvement of Chemical Stability of Tiagabine HCl

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Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line

Cited by 40 publications

References 9 publications

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl‐β‐cyclodextrin

2-Hydroxypropyl &#946;-Cyclodextrin: A New Tool for the Improvement of Chemical Stability of Tiagabine HCl

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2-Hydroxypropyl β-Cyclodextrin: A New Tool for the Improvement of Chemical Stability of Tiagabine HCl