Complexe de sodium de l'ionophore monensine B monohydraté

Abstract

A sodium complex of monensin B isolated and purified by chromatography has crystallized as a monohydrate (Mon B)Na.H20, C35H59NaOII.H20, M r = 696.8. The cell is orthorhombic, space group P2~212 r with a = 12.135(1), b = 14.976(2), c = 20.683 (1)A, V= 3758.8A 3, Z = 4, D x = 1.23 Mgm -3, F(000) = 1580. The structure has been refined to R = 0.029 (for 107 atoms) for 2349 observed reflexions. The heterocyclic part of the anion wraps the cation which is coordinated to six O atoms; two hydrogen bonds between the carboxylate group of one end and the two hydroxyl groups of the other end close the anionic ring. This conformation is very similar to that already known for complexes of monensin A. The water molecule is hydrogen bonded to two anions in a new mode compared to the cell organization of the other complexes.

Synthesis, structure and antimicrobial activity of manganese(II) and cobalt(II) complexes of the polyether ionophore antibiotic Sodium Monensin A

“…Monensins readily complex alkali ions with an affinity which decreases in the order Na + > K + > Rb + > Li + > Cs + . Their mononuclear complexes together with those ones of the Ag + and Tl + ions are characterized both in solution and in solid state [7][8][9][10][11][12][13][14][15][16][17]. In all reported cases the monovalent metal ion is coordinated by six oxygens to create shell-like complexes as it was proved by X-ray crystallography.…”

“…To the best of our knowledge, in most studies performed up to now, acid Monensin A, its derivatives or acid Monensin B as initial reagents have been used [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][31][32][33][34][35][36][37][38][39][40], although the complex Ag + (Mon À ) was prepared from a Sodium Monensin in basic water-ethanol solutions [12].…”

First Divalent Metal Complexes of the Polyether Ionophore Monensin A:X-Ray Structures of [Co(Mon)2(H2O)2] and [Mn(Mon)2(H2O)2] and their Bactericidal Properties

“…Monensin is known as a monovalent polyether ionophore since it readily complexes alkali ions with an affinity increasing in the order Cs + < Li + < Rb + < K + < Na + [18][19][20]. The crystallographic studies on a series of Monensin metal complexes showed the formation of shell-like complexes in the solid state [21][22][23][24][25][26][27]. The metal center is coordinated with six oxygen atoms originating from the cyclic ether units and from the hydroxyl groups of the ligand.…”

Crystal structure and properties of the copper(II) complex of sodium monensin A

“…The complexes of ionophorous antibiotics, and especially of monensin, known up to date, are those obtained with alkali metal ions [8][9][10][11][12][13][14][15][16][17][18][19] and Ag + [10,11,20,21]. The metal compounds were characterized by single crystal X-ray diffraction and their structures were determined both in solid state and in solution using various spectroscopic methods.…”