Crystal structure and properties of the copper(II) complex of sodium monensin A

Pantcheva, Ivayla; Dorkov, Petar; Atanasov, Vasil; Mitewa, M.; Shivachev, Boris; Nikolova, Rositsa; Mayer‐Figge, Heike; Sheldrick, William S.

doi:10.1016/j.jinorgbio.2009.08.007

Cited by 26 publications

(17 citation statements)

References 46 publications

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“…The activity of compounds is determined as their minimum inhibitory concentration [MIC, (lM)], which is the lowest concentration causing the visible inhibition of the bacteria growth. Details concerning the experimental procedures using the double layer agar hole diffusion method were carried in accordance with the literature (Andrews 2001) and were similar to those reported previously Pantcheva et al 2008Pantcheva et al , 2009.…”

Section: Cytotoxicity Assay (Determination Of Mic)mentioning

confidence: 85%

“…The hypothesis that monensin possesses previously unknown reactivity prompted our group to start an extensive study on the coordination ability of the ligand towards di-and three-valent metal ions. In our previous publications we demonstrated that monensin could form two types of divalent transition metal complexes depending on the chemical form used in the reactions Pantcheva et al 2008Pantcheva et al , 2009). The compounds obtained possess enhanced antimicrobial activity towards Gram(?…”

Section: Introductionmentioning

confidence: 99%

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First solid state alkaline-earth complexes of monensic acid A (MonH): crystal structure of [M(Mon)2(H2O)2] (M = Mg, Ca), spectral properties and cytotoxicity against aerobic Gram-positive bacteria

Pantcheva¹,

Zhorova²,

Mitewa³

et al. 2009

Biometals

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Alkaline-earth metal complexes of the monoanionic form of the polyether ionophore monensin A were isolated for the first time in solid state and were structurally characterized using various spectroscopic methods (IR, NMR, FAB-MS). The stoichiometric reaction of monensic acid (MonH) with M(2+) (M = Mg, Ca) in the presence of an organic base leads to the formation of mononuclear complexes of composition [M(Mon)(2)(H(2)O)(2)]. The structures of magnesium (1) and calcium (2) monensin complexes in the solid state were established by single crystal X-ray crystallography. The complexes crystallize as [Mg(Mon)(2)(H(2)O)(2)]x5MeCN (1) and [Ca(Mon)(2)(H(2)O)(2)]xH(2)Ox5MeCN (2) in the monoclinic P21 space group. The alkaline-earth metal ion is placed in a distorted octahedral environment, defined by two monensin anions acting as bidentate ligands in the equatorial plane of the complex as well as by two water molecules occupying the axial positions of the inner coordination sphere. The bactericidal activity of 1 and 2 was evaluated against aerobic Gram-positive microorganisms applying the double layer agar hole diffusion method.

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Section: Cytotoxicity Assay (Determination Of Mic)mentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

First solid state alkaline-earth complexes of monensic acid A (MonH): crystal structure of [M(Mon)2(H2O)2] (M = Mg, Ca), spectral properties and cytotoxicity against aerobic Gram-positive bacteria

Pantcheva¹,

Zhorova²,

Mitewa³

et al. 2009

Biometals

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“…the complexes of ni(ii) (5) and Zn(ii) (6) are effective against B. subtilis, B. mycoides and C. perfringens, although they do Pantcheva et al (7,8,9,10) B. mycoides c Pantcheva et al (7,8,9,10) not show toxicity against S. lutea in the studied concentration range. notably, the Mn(ii) complex (4) was shown to be the least toxic among the metal(ii) compounds against Gram-positive aerobic bacteria.…”

Section: A Series Of Monensin Metal(ii) Compounds [M(mon) 2 (H 2 O) 2 ]mentioning

confidence: 89%

“…in this respect we have recently studied the ability of these antibiotics, especially Monensin, to coordinate divalent bio-and toxic metal ions. We were able to characterize complexes of various compositions and different structures depending on the antibiotic applied (acidic or sodium form) as well as on the metal(ii) ion tested (7,8,9,10). our studies revealed that the activity of metal(ii) complexes of Monensin and Salinomycin is enhanced compared to the non-coordinated antibiotics against Gram-positive aerobic bacteria.…”

Section: Introductionmentioning

confidence: 92%