Complexes of the antimicrobial ciprofloxacin with soil, peat, and aquatic humic substances

Aristilde, Ludmilla; Sposito, Garrison

doi:10.1002/etc.2214

Cited by 65 publications

(44 citation statements)

References 62 publications

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“…If adsorption is the principal mechanism for sequestration of ciprofloxacin in organic wastes, this mechanism is likely to be enhanced by the compost process because composting reduces particle sizes and therefore increases total adsorptive surface area (7). Presumably, the same adsorptive mechanisms would also neutralize other antibiotics and pharmaceuticals that can be sequestered via adsorptive forces (13,29). While it is probable that other mechanisms such as biological degradation and high temperature contribute to the degradation of ciprofloxacin in the compost, the methods used in this study did not allow separation of these effects.…”

Section: Discussionmentioning

confidence: 93%

Ciprofloxacin Residues in Municipal Biosolid Compost Do Not Selectively Enrich Populations of Resistant Bacteria

Youngquist

Liu

Orfe

et al. 2014

Appl Environ Microbiol

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bBiosolids and livestock manure are valuable high-carbon soil amendments, but they commonly contain antibiotic residues that might persist after land application. While composting reduces the concentration of extractable antibiotics in these materials, if the starting concentration is sufficiently high then remaining residues could impact microbial communities in the compost and soil to which these materials are applied. To examine this issue, ciprofloxacin was added to biosolid compost feedstock to achieve a total concentration of 19 ppm, approximately 5-fold higher than that normally detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS) (1 to 3.5 ppm). This feedstock was placed into mesh bags that were buried in aerated compost bays. Once a week, a set of bags was removed and analyzed (treated and untreated, three replicates of each; 4 weeks). Addition of ciprofloxacin had no effect on the recovery of resistant bacteria at any time point (P ‫؍‬ 0.86), and a separate bioassay showed that aqueous extractions from materials with an estimated 59 ppm ciprofloxacin had no effect on the growth of a susceptible strain of Escherichia coli (P ‫؍‬ 0.28). Regression analysis showed that growth of the susceptible strain of E. coli can be reduced given a sufficiently high concentration of ciprofloxacin (P < 0.007), a result that is consistent with adsorption being the primary mechanism of sequestration. While analytical methods detected biologically significant concentrations of ciprofloxacin in the materials tested here, the culture-based methods were consistent with the materials having sufficient adsorptive capacity to prevent typical concentrations of ciprofloxacin residues from selectively enriching populations of resistant bacteria.

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Section: Discussionmentioning

confidence: 93%

Ciprofloxacin Residues in Municipal Biosolid Compost Do Not Selectively Enrich Populations of Resistant Bacteria

Youngquist

Liu

Orfe

et al. 2014

Appl Environ Microbiol

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“…The composition of humic substances depends on the initial biomaterial content and on the groups of microorganisms, under the action of which the transformation occurs (Aristilde and Sposito 2013). Industrially produced humic materials demonstrated no or insignificant impact on the surface tension of their solutions, whereas the humic acids isolated from peat demonstrated significant impacts on the surface tension of their solutions, i.e.…”

Section: Introductionmentioning

confidence: 95%

Surface properties of humic acids from peat and sapropel of increasing transformation

et al. 2015

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Humic substances are complex, organic substances occurring in natural media such as water, soils and sediments. Humic substances represent the highest pool of recent carbon on earth, and they influence climate, soil fertility and depollution. In spite of such importance, the structure and properties of humic substances are largely unknown. We studied the surfactant activity of humic acids from peat of increasing degrees of humification and sapropel, sampled in the Upa River of the Tula region. We measured critical micelle concentration (CMC) of humic acids of different ages. Our results show that CMC decreases from 1.5 g/100 ml for the less transformed sapropel, to 1.0 g/100 ml for the medium-transformed mesotrophic sphagnum peat, to 0.25 g/100 ml for the most transformed eutrophic alder peat. We also found that the limiting adsorption of humic acids from the younger sapropel, of 7.1 9 10 -6 mol/m 2 , and from sphagnum peat, of 7.6 9 10 -6 mol/m 2 , are higher than the limiting adsorption of humic acids from the older eutrophic alder peat, of 3.3 9 10 -6 mol/m 2 .

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“…Humic substances (HS), as the major fraction of DOM in natural water, are expected to play primary roles in binding with antibiotics of both hydrophilic and hydrophobic moieties owing to H-bonding and other intermolecular interactions 17 . It has been shown that ciprofloxacin can bind with HS due to intermolecular interactions, and both the pH and the types of HS determine the ciprofloxacin-HS complexes 17 .…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that ciprofloxacin can bind with HS due to intermolecular interactions, and both the pH and the types of HS determine the ciprofloxacin-HS complexes 17 . Of note, under environmentally relevant pH conditions, the primary driver for ciprofloxacin adsorption onto soil organic matter is a cation-exchange reaction involving a mediating electrostatic attraction between the positively charged group of the antibiotic and the negatively charged HS group 17, 21 . In fact, the binding of ciprofloxacin with HS mainly depends on the van der Waals interaction, H-bonding and electrostatic interactions 17 .…”

Section: Introductionmentioning

confidence: 99%

DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties

Liang

Lü

Meng

2017

Sci Rep

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In this study, membrane filtration tests showed that the membrane rejection degree of difloxacin hydrochloride (DFHC) increased significantly in the presence of Suwannee River DOM or Aldrich humic acid (2–10 mg-C/L). Titration experiments showed that the excitation and emission of Peak R belonging to DFHC exhibited blue shifts by 5 nm and 10 nm, respectively, in the presence of DOM. The presence of DFHC can, in turn, lead to more significant overlapping of the fluorescence peaks of the Suwannee River DOM and Aldrich humic acid. The parallel factor analysis (PARAFAC) of the excitation-emission matrix (EEM) spectra can well decompose the components belonging to DFHC from the DOM + DFHC mixtures. The maximum fluorescence intensity (FI max) of the antibiotic-like component (C1) sharply decreased upon the initial addition of DOM. More specifically, the Aldrich humic acid showed a larger quenching effect on DFHC than the Suwannee River DOM. The stability constants (K M) obtained by the Ryan and Weber model also corroborated that the Aldrich humic acid had a much higher binding stability (K M = 4.07 L/mg) than the Suwannee River DOM (K M = 0.86 L/mg). These results have great implications for our understanding of the membrane filtration behavior of trace contaminants in natural waters.

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Complexes of the antimicrobial ciprofloxacin with soil, peat, and aquatic humic substances

Cited by 65 publications

References 62 publications

Ciprofloxacin Residues in Municipal Biosolid Compost Do Not Selectively Enrich Populations of Resistant Bacteria

Ciprofloxacin Residues in Municipal Biosolid Compost Do Not Selectively Enrich Populations of Resistant Bacteria

Surface properties of humic acids from peat and sapropel of increasing transformation

DOM-mediated membrane retention of fluoroquinolone as revealed by fluorescence quenching properties

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