Compliance and diameter in the human abdominal aorta—The influence of age and sex

Sonesson, Björn; Hansen, Flemming; Stale, Håkan; Länne, Toste

doi:10.1016/s0950-821x(05)80718-2

Cited by 222 publications

(169 citation statements)

References 28 publications

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“…39,40 However, the relation between altered mechanical properties of blood vessels and atherosclerosis is complex and probably involves both structural and functional influences that have led to conflicting reports in the literature. 41 An attractive hypothesis consistent with the data are that altered endothelial function is at the root of the large and small artery compliance reduction with aging. Endothelial release of nitric oxide (NO) is impaired with aging, atherosclerosis, and diabetes.…”

Section: Figurementioning

confidence: 67%

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

et al. 1999

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Abstract-The objective of this study was to evaluate age-related changes in pulsatile arterial function. Aging alters arterial pulsatile function and produces consistent changes in the pressure pulse contour. A reduced systemic arterial compliance that can be derived from analysis of the pulse contour is regarded as the best clinical index of impaired pulsatile arterial function and may mark the presence of early vascular damage. We analyzed intra-arterial brachial artery waveforms in 115 healthy normotensive volunteers (83 men, 32 women) and radial artery waveforms obtained with the use of a calibrated tonometer device in 212 healthy volunteers (147 women, 65 men). A computer-based assessment of the diastolic pressure decay and a modified Windkessel model of the circulation were used to quantify changes in arterial waveform morphology in terms of large artery or capacitive compliance, oscillatory or reflective compliance in the small arteries, inertance, and systemic vascular resistance. Large artery compliance and oscillatory compliance correlated negatively with age for both invasive and noninvasive groups (rϭϪ0. 50 and rϭϪ0.55; rϭϪ0.37 and rϭϪ0.66; PϽ0.001 for all). The slopes of the regression lines for the decline in oscillatory compliance with age were significantly steeper than those recorded for large artery compliance estimates. The change in blood pressure with age independently contributed to the decrease in large artery compliance but not oscillatory compliance in both groups. Consistent age-related changes were found in the pressure pulse contour by analysis of waveforms obtained invasively or noninvasively from the upper limb. The change in the oscillatory or reflective compliance estimate was independent of blood pressure change and may represent a better marker than large artery or capacitive compliance of the degenerative aging process in altering pulsatile arterial function. (Hypertension. 1999;33:1392-1398.)Key Words: age Ⅲ compliance Ⅲ resistance Ⅲ impedance A daptations in the arterial vasculature play a critical role in influencing cardiovascular hemodynamics with advancing age. 1 The generalized structural and functional changes in the arterial circulation contribute to alterations in regional blood flow, progression of atherogenesis, and the microvascular abnormalities that occur during senescence. 2 In large arteries, aging results in progressive deposition of calcium salts, fraying and fragmentation of elastin, and an increase in the number and cross-linking of collagen fibers that alter the compliance characteristics of the vessel wall. 3 A rigid aorta is less able to buffer the pulsatile output from the heart; it contributes to an increase in systolic blood pressure and left ventricular afterload and a decrease in diastolic blood pressure and impaired coronary perfusion. Recent evidence suggests that an increase in pulse pressure is accompanied by progressive vessel wall damage and atherogenesis and is associated with an increase in cardiac morbidity and mortality rates. 4,5 In addi...

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Section: Figurementioning

confidence: 67%

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

et al. 1999

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“…In a study investigating the abdominal aorta in 69 subjects, the β stiffness index, in contrast to the elastic modulus (Ep), was not affected significantly by an increase in blood pressure 18 . This is, of course, an important strength of the β stiffness index.…”

Section: Discussionmentioning

confidence: 90%

“…Our study shows a relatively strong (beta=0.18), positive relationship between (HOMA-IR) and follow-up aortic stiffness among women, but not among men. Only a few studies have previously investigated the abdominal aorta distensibility using echo-tracking techniques, reporting for example that the aorta is more prone to stiffening than the carotid arteries 17 and that aortic stiffness is positively associated with age and male gender 18 . However, none of previous publications using this method, to our knowledge, have stated objectives similar to our study.…”

Section: Discussionmentioning

confidence: 99%

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Link to publication Citation for published version (APA): Gottsäter, M., Länne, T., & Nilsson, P. M. (2014). Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Journal of Human Hypertension, 28(7), 456-460. DOI: 10.1038456-460. DOI: 10. /jhh.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractArterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment -insulin resistance (HOMA-IR), lipids and abdominal obesity.This study includes 335 subjects from Malmö, Sweden, examined in 1991 and again at follow-up in 1998-2000. Ultrasound measurement of the abdominal aorta was performed at follow-up investigation.In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (beta=0.18, p=0.03) and a negative association between high density lipoprotein and aortic stiffness (beta=-0.23, p=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.

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“…It is well known that atherosclerotic risk factors such as a high cholesterol level, hypertension, cigarette smoking, and diabetes mellitus aggravate vascular alterations in aging; subjects who bear major atherosclerotic risk factors have stiffer arteries 6,10,11 or thicker intima-media than 178 healthy subjects. [12][13][14][15][16] To examine the alteration of structural, functional, and hemodynamic vascular parameters during aging and not the effect of overlying atherosclerotic risk factors, it was necessary to screen the study population for the absence of major atherosclerotic risk factors or existing cardiac disease.…”

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confidence: 99%

Structural, Functional, and Hemodynamic Changes of the Common Carotid Artery With Age in Male Subjects

Schmidt‐Trucksäss

Grathwohl

Schmid

et al. 1999

ATVB

124

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Abstract-Aging of the common carotid artery (CCA) is associated with different principal structural, functional, and hemodynamic changes, which are often influenced by several atherosclerotic risk factors, so that it is difficult to estimate the exclusive effect of aging on this process. Studies dealing with vascular aging of the CCA usually assess only single, dimensional, or functional parameters, although it is likely that there are interactions and probably differences between them. Moreover, regional vascular blood flow characteristics are often not taken into consideration. Therefore, the aim of the study was to assess the age-related multiparametric changes of the CCA properties with ultrasound in 69 male subjects between the ages of 16 and 75 (42.4Ϯ16.5 years), who were screened for the absence of major atherosclerotic risk factors or existing vascular disease. As a result, the intima media thickness (0.052 mm/10 y) and diastolic diameter (0.17 mm/10 y) increased nearly linearly with age (rϭ0. 60, PϽ0.001; and rϭ0.46, PϽ0.001, respectively). The absolute diastolic/systolic diameter change diminished by 0.10 mm/10 y (rϭϪ0.73, PϽ0.001) and peak expansion velocity dropped by 0.12 cm/s per 10 years (rϭϪ0.62, PϽ0.001) highly significantly with age. The peak blood flow velocity decreased continuously with age (rϭϪ0.67, PϽ0.00) by 9.3 cm/s per 10 years. According to multiple regression analysis, peak blood flow velocity seems to reflect the changes of several structural and functional parameters in one; intima-media thickness was determined by diastolic arterial diameter and age as independent variables. The data indicate that a multiparametric assessment may contribute to a better understanding of vascular aging and might be the basis for further studies to evaluate the association of atherosclerotic risk factors and/or major vascular disease with local changes in the CCA. Key Words: carotid artery Ⅲ aging Ⅲ arterial stiffness Ⅲ ultrasound V ascular aging is associated with different principal structural and functional changes; ie, intima-media thickening, 1,2 arterial dilation, 3,4 and the deterioration of elastic wall properties with vascular stiffening 5-7 belong to this process. Each of these has an impact on vascular blood flow and the local and/or systemic hemodynamics interact with the structure and function of the artery. For example, both the elevation of blood pressure and stroke volume increase the wall shear rate and may thus lead to a midterm increase in the thickness of the intima-media 8 or structural adaptation in the form of a greater vascular diameter. 9 Although these interactions are known, very few studies take all these structural, functional, and hemodynamic parameters into consideration, which might be of interest to enable a better understanding of the relation of aging to the named arterial changes. Furthermore, only little data exist on the differences in the progression of these alterations.It is well known that atherosclerotic risk factors such as a high cholesterol level, hyperten...

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Compliance and diameter in the human abdominal aorta—The influence of age and sex

Cited by 222 publications

References 28 publications

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Structural, Functional, and Hemodynamic Changes of the Common Carotid Artery With Age in Male Subjects

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