Background:-The Integrated Management of Newborn and Childhood Illness strategy encompasses a range of interventions to prevent and manage the major childhood illness, both in health facilities and in the home. Information on actual compliance of care takers in integrated management of newborn and childhood illness is important for program planners, policy makers, health care providers and care takers to design appropriate local and national intervention plan, to increase community participation and to improve knowledge of care takers. Based on our knowledge there are limited studies regarding to care takers compliance towards integrated management of new born and childhood illness in the study area. Therefore the result of this study used for design appropriate intervention.Objective: - The objective of this study was to assess the care takers compliance and associated factors in integrated management of newborn and childhood illness with respect to counseling.Methods:-Community based cross-sectional study was conducted. The study populations were all care takers of under-five children who attended integrated management of newborn and childhood illness clinic at health center. A total of 394 respondents were randomly selected by using systematic random sampling method from the seven health centers. Information on the care takers compliance was collected using structured, pre-tested questionnaire. Data entry and analysis were conducting using Statistical Package for Social Science version 16. Significance of the study was presented by using adjust odd ratio, confidence interval and p value. The result was presented in texts, tables and graphs.Result:-Three hundred seventy three care takers with under-five year children were voluntary to be interviewed, making the response rate 94.7 %. The findings of this study showed that 144(39%) were compliance to antibiotic treatment and 102(27.3%) were compliance to counseling. Compliance to counseling was significantly associated with age categories between 25-34 year with (AOR=2.118, 95% CI: 1.042, 4.305), post-secondary education with (AOR=2.959, 95% CI: 1.354, 6.463), knowledge with (AOR= 2.574, 95% CI: 1.482, 4.469), trust on health workers with (AOR= 2.781, 95% CI: 1.344, 5.752) and distance with (AOR= 2.214, 95% CI: 1.254, 3.91).Conclusion: The finding of this study revealed that the high rates of noncompliance with antibiotic treatment were identified. Therefore, implementation of integrated management of childhood illness activities at all levels should be strengthened and need to improve the social status of care takers in order to reduce child hood morbidity and mortality.