Complication Rate of Transrectal Ultrasound Guided Prostate Biopsy: A Comparison Among 3 Protocols With 6, 10 and 15 Cores

Berger, Andreas; Gozzi, Christian; Steiner, Hannes; Frauscher, Ferdinand; Varkarakis, John; Rogatsch, Hermann; Bartsch, Georg; Horninger, Wolfgang

doi:10.1097/01.ju.0000116449.01186.f7

Cited by 179 publications

(160 citation statements)

References 16 publications

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“…The incidence of complications is not increased by increasing the number of biopsy cores (16,17). In our study as well, none of the patients in either the 6-core or 12-core biopsy groups showed rectal bleeding, need for anesthesia, or prolongation of hospitalization.…”

Section: Commentsmentioning

confidence: 61%

Retrospective study comparing six - and twelve-core prostate biopsy in detection of prostate cancer

Tobiume¹,

Yamada²,

Nakamura³

et al. 2008

Int. braz j urol.

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Objective: We compared the safety and efficacy of the 12-core biopsy with those of the conventional systematic 6-core biopsy with PSA levels between 4.1 and 20.0 ng/mL. Materials and Methods: This study included 428 patients who underwent a 6-core biopsy and 128 patients who underwent a 12-core biopsy. Biopsies were performed transrectally under ultrasound guidance. The 12-core biopsy scheme involved obtaining 6 far lateral cores. Results: For patients with PSA level between 4.1 and 10.1 ng/mL, 47 of the 265 patients who underwent 6-core biopsy and 32 of the 91 patients who underwent a12-core biopsy were diagnosed with prostate cancer (p = 0.0006). Among the patients with a PSA level between 10.1 and 20.0 ng/mL, 48 of 163 patients who underwent the 6-core biopsy and 16 of 37 patients who underwent the 12-core biopsy were diagnosed with prostate cancer (p = 0.0606). Three of the 95 patients who were diagnosed with prostate cancer through the 6-core biopsy and 12 of the 48 patients who were diagnosed through the 12-core biopsy had cancer located in the anterior apex. The 12-core biopsy increased the diagnostic rate in the apex (p = 0.001). No statistically significant differences were found in incidence of complications. Conclusion: We concluded that the 12-core biopsy is a safe and more effective procedure for increasing the diagnostic rate of prostate cancer than the 6-core biopsy in patients with PSA level between 4.1 and 10.0 ng/mL, and the most useful anatomical area to be added was found to be cores from the anterior apex.

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Section: Commentsmentioning

confidence: 61%

Retrospective study comparing six - and twelve-core prostate biopsy in detection of prostate cancer

Tobiume¹,

Yamada²,

Nakamura³

et al. 2008

Int. braz j urol.

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“…Short term complications from biopsy were similar. Berger et al compared complication rates between 6, 10, and 15-core biopsy protocols (19). Their study revealed no difference in major complications (fever, prostatitis, epididymitis, or urinary retention), although there was an increased number of patients with hematospermia after 10-core and 15-core biopsies.…”

Section: Discussionmentioning

confidence: 99%

Biopsy Related Prostate Status Does Not Affect on the Clinicopathological Outcome of Robotic Assisted Laparoscopic Radical Prostatectomy

Choi

Kang

et al. 2009

Cancer Res Treat

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“…Berger et al reported an overall bleeding rate of 2.3%. In this TRUS-guided series, only 0.6% of patients experienced prolonged hematochezia or required surgical intervention for bleeding control, with no significant correlation with the number of cores taken 5 . The occurrence of hematochezia after MRI in-bore prostate biopsy ranged from 11% to 17% 3 , with no significant advantages offered by this approach over traditional TRUS-guided PB in terms of incidence and duration of bleeding in this population 14 .…”

Section: Rectal Bleedingmentioning

confidence: 99%

“…The presence of visible blood in the ejaculate is the most variably reported complication after prostate biopsy, ranging from 1.1%-92.6% 1,5,7,11,13,17 . Unlike hematuria or rectal bleeding, hematospermia could have a transient detrimental effect on sexual activity or trigger anxiety 7,17 .…”

Section: Hematospermiamentioning

confidence: 99%

Complications After Systematic, Random, and Image-guided Prostate Biopsy

et al. 2017

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Evidence Synthesis: The most frequent complication after PB is minor and self-limiting bleeding (hematuria and hematospermia), irrespective of the biopsy approach. Occurrence of rectal bleeding was comparable among traditional TRUS-guided and image-guided PB. Almost 25% of patients experience lower urinary tract symptoms, but only a few have urinary retention, with higher rates after transperineal approach. Temporary erectile dysfunction is not negligible, with a return to baseline after 1-6 months. The incidence of infective complications is being increasing, with higher rates among men with medical comorbidities and older age. Transperineal and in-bore MRI targeted biopsy may reduce the risk of severe infectious complications. Mortality after PB is uncommon, irrespective of biopsy technique. Conclusions:Complications after PB are frequent but often self-limiting. The incidence of hospitalization due to severe infections is continuously increasing. Still, a careful appraisal of 3 patient's general health status, risk factors and likelihood of antimicrobial resistance should be done before scheduling a PB. Patient Summary:In this paper we reviewed the variety and incidence of complications after prostate biopsy. Even if frequent, seldom represent a problem for the patient. The most troublesome complications are infections. In order to minimize this risk, a careful evaluation of patient's medical condition must be done before biopsy.4

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Complication Rate of Transrectal Ultrasound Guided Prostate Biopsy: A Comparison Among 3 Protocols With 6, 10 and 15 Cores

Cited by 179 publications

References 16 publications

Retrospective study comparing six - and twelve-core prostate biopsy in detection of prostate cancer

Retrospective study comparing six - and twelve-core prostate biopsy in detection of prostate cancer

Biopsy Related Prostate Status Does Not Affect on the Clinicopathological Outcome of Robotic Assisted Laparoscopic Radical Prostatectomy

Complications After Systematic, Random, and Image-guided Prostate Biopsy

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