Complications Associated With Amniocentesis in the Third Trimester of Pregnancy

Ramírez-Montiel, Martha Laura; Casillas-Barrera, Manuel; Morales-Morales, Martha P.; Ortiz, Mario I.; Leon, Omar de Lara-Diaz de Lopez; Carrasco-Blancas, Erika R.; Morales, Leonardo Fabio

doi:10.14740/jcgo452w

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…93,94 However, many of these biomarkers are only predictive of sPTB if measured in amniotic fluid collected through an invasive process known as amniocentesis. 95 The process itself carries some risks to the mother and/or foetus, and since the advent of non-invasive prenatal testing using cell-free foetal DNA sequencing, the procedure is no longer commonly performed. 96 It is thus important to consider non-invasive alternatives such as CVF, plasma or urine for novel proteomic or metabolomic biomarkers.…”

Section: Human Protein and Metabolite Biomarkers Of Sptbmentioning

confidence: 99%

Advances in mass spectrometry technologies to characterize cervicovaginal microbiome functions that impact spontaneous preterm birth

Masson

Wilson

Hamzah

et al. 2023

American J Rep Immunol

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Preterm birth (PTB) is a leading cause of morbidity and mortality in young children. Infection is a major cause of this adverse outcome, particularly in PTBs characterised by spontaneous rupture of membranes, referred to as spontaneous (s)PTB. However, the aetiology of sPTB is not well defined and specific bacteria associated with sPTB differ between studies and at the individual level. This may be due to many factors including a lack of understanding of strain‐level differences in bacteria that influence how they function and interact with each other and the host. Metaproteomics and metabolomics are mass spectrometry‐based methods that enable the collection of detailed microbial and host functional information. Technological advances in this field have dramatically increased the resolution of these approaches, enabling the simultaneous detection of thousands of proteins or metabolites. These data can be used for taxonomic analysis of vaginal bacteria and other microbes, to understand microbiome‐host interactions, and identify diagnostic biomarkers or therapeutic targets. Although these methods have been used to assess host proteins and metabolites, few have characterized the microbial compartment in the context of pregnancy. The utilisation of metaproteomic and metabolomic‐based approaches has the potential to vastly improve our understanding of the mechanisms leading to sPTB.

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Section: Human Protein and Metabolite Biomarkers Of Sptbmentioning

confidence: 99%

Advances in mass spectrometry technologies to characterize cervicovaginal microbiome functions that impact spontaneous preterm birth

Masson

Wilson

Hamzah

et al. 2023

American J Rep Immunol

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“…It has previously been shown that twin pregnancies have a higher risk of developing chromosomal abnormalities. In addition to genetic testing, amniocentesis is used in third-trimester screening tests to check for markers of fetal lung maturation in amniotic fluid (Boyer, Cameron, Munoz-Maldonado, Bronsteen, Comstock, Lee, & Goncalves, 2014;Ramirez-Montiel, Casillas-Barrera, Morales-Morales, Ortiz, Carrasco-Blancas, & Morales, 2017). The main concern is fetal complications.…”

Section: Introductionmentioning

confidence: 99%

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Masihi¹,

Shahbazian²,

Barati³

et al. 2020

JMBR

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Introduction: Amniocentesis is one of the most widely used diagnostic interventions but despite its many advantages, it has side effects such as fetal loss. The importance of fetal loss after amniocentesis in twin pregnancies is very important and some researchers believe that in twin pregnancies, the risk of fetal loss after amniocentesis is higher than singleton. Therefore, the present study examined the rate of fetal loss after amniocentesis in twin pregnancies compared to singleton pregnancies. Methods: This prospective descriptive-analytical study was performed on 712 mothers with singleton (628 cases) and twin (84 cases) pregnancies who referred to the obstetrics and gynecology clinic of Imam Khomeini Hospital in Ahvaz with Amniocentesis due to several reason during 2016-2020. A questionnaire containing information such as age, gestational age, number of pregnancies, childbirth and abortion, the cause of the diagnostic test, quarterly screening and NT ultrasound, and the result of amniocentesis were completed for patients. Patients were followed up during the first week, two weeks, and 60 days after amniocentesis, and finally data were analyzed by SPSS version24. Results: The mean age of the patients was 31.96 ± 6.33 years and the mean gestational age at amniocentesis for all patients was 15.37 ± 0.7. The mean NT in patients in the two groups did not differ significantly (1.60±0.44 vs 1.54±4.64, p=0.56). the prevalence of preterm in twin mothers was 13.1% and, in the singleton was 1.75% (p = 0.01). The occurrence of fetal loss was 2.4% in the twin group and 2.07% in the singleton group which was not statistically significant (p = 0.56). in the twin group, one (50%) fetal loss occurred in the first week and another one (50%) occurred between 15 and 60 days. But in the singleton group, 7 cases (63.6%) in the first week, 1 case (9%) in 15 to 60 days, and 3 cases (27.3) after more than 60 days lost the fetus. Previous pregnancy records in twins showed that the mean Gravid (p = 0.01), Parity (p = 0.01) and Living child (p = 0.02) in preterm twins' patients were statistically significantly lower than in the term patients. Conclusion: Our findings show that fetal loss following amniocentesis in twin pregnancies does not increase significantly compared to singleton pregnancies. However, our findings require repeated study in bigger sample size and as multi-centered as possible then It can be generalized to wider communities.

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Maternal and fetal ultrasonographic characteristics, vulvar temperature, and vaginal mucous impedance as variables associated with the onset of parturition in term and induced pre-term ewes

Rodriguez

Santos

Uscátegui

et al. 2020

Animal Reproduction Science

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Complications Associated With Amniocentesis in the Third Trimester of Pregnancy

Cited by 8 publications

References 11 publications

Advances in mass spectrometry technologies to characterize cervicovaginal microbiome functions that impact spontaneous preterm birth

Advances in mass spectrometry technologies to characterize cervicovaginal microbiome functions that impact spontaneous preterm birth

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Maternal and fetal ultrasonographic characteristics, vulvar temperature, and vaginal mucous impedance as variables associated with the onset of parturition in term and induced pre-term ewes

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