Complications Associated With the Use of Recombinant Human Bone Morphogenic Protein–2 in Ridge Augmentation: A Case Report

Abstract

This case report aims to describe in detail a complication associated with resorption of regenerated bone following implant placement and ridge augmentation using recombinant human bone morphogenic protein-2 (rhBMP-2) in combination with allograft and xenograft. Bilateral maxillary sinus and ridge augmentation procedures were completed using rhBMP-2 combined with allograft and xenograft. Five months later, significant bone augmentation was achieved, which allowed for the placement of 4 implants. Upon stage 2 surgery, significant dehiscence was noted in all implants. Treatment steps to address this complication included implant removal, guided bone regeneration with xenograft only, and placement of new implants followed by soft-tissue grafting. At the time of publication, this patient is status 1½ years post case completion with maintenance of therapy outcomes. Off-label use of rhBMP-2 has gained significant acceptance in implant dentistry. However, there is limited evidence regarding the bone maturation process when rhBMP-2 is combined with other biomaterials. More research may be needed regarding the timing and process of bone healing in the presence of rhBMP-2, in an effort to avoid surgical complications.

The role of antimiR-26a-5p/biphasic calcium phosphate in repairing rat femoral defects

“…It was previously reported that the addition of autologic osteoblasts to biomaterials promoted new bone formation, and increased levels of growth factors such as bone morphogenetic protein 2 (BMP-2) (14,15). However, the short-lived in vivo efficacy of BMP-2 and the difficulty of osteoblast isolation limits their usage (16,17). Recent studies have therefore focused on the combination of osteogenic gene-modified mesenchymal stem cells (MSCs) and BCPs for TEBGs, and an important goal is to identify the most effective osteogenic genes in this process (18,19).…”