Complications of gastroesophageal reflux in patients with cystic fibrosis

Bendig, Donald W.; Seilheimer, Dan K.; Wagner, Milton L.; Ferry, George D.; Harrison, Gunyon M.

doi:10.1016/s0022-3476(82)80748-8

Cited by 57 publications

(18 citation statements)

References 10 publications

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“…Most of our patients (63%) had GER symptoms and almost a quarter (24%) had frequent symptoms. Previous studies [6][7][8][9] of both adults and children with CF have reported a prevalence of GER symptoms of 25-81%, though they have employed differing criteria. Two small studies (n = 50, n = 10) comprised exclusively of adults with CF found a high prevalence (80%-88%) of GERD by pH probe in patients with GER symptoms and patients awaiting and having received a lung transplant respectively [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…Over the last 30 years, advances in care have resulted in a growing population of adults with cystic fibrosis (CF) [5], but the impact of GERD on this population remains poorly understood. GERD is more common in infants and children with CF than in the general population [6][7][8][9], but there are few comparable studies in adults [10,11]. Furthermore, evidence that GERD adversely impacts lung function in CF is limited [12].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of gastroesophageal reflux in adults with cystic fibrosis

Sabati

Kempainen

Milla

et al. 2010

Journal of Cystic Fibrosis

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics of gastroesophageal reflux in adults with cystic fibrosis

Sabati

Kempainen

Milla

et al. 2010

Journal of Cystic Fibrosis

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“…Reported complications include reflux oesophagitis11 and peptic strictures 12. In view of the improved long term survival, other potential complications may need to be considered, including Barrett’s metaplasia13 and, potentially, adenocarcinoma of the oesophagus 14.…”

mentioning

confidence: 99%

Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis

Heine

Button

Olinsky

et al. 1998

Archives of Disease in Childhood

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Aim-To establish the incidence of pathological gastro-oesophageal reflux (GOR) in newly diagnosed infants with cystic fibrosis and to identify clinical predictors of increased reflux. Methods-26 infants with cystic fibrosis less than 6 months of age (14 male, 12 female; mean (SEM) age 2.1 (0.21) months, range 0.8 to 5.6 months) underwent prolonged oesophageal pH monitoring (mean duration 27.1 (0.49) hours; range 21.3 to 30.2 hours). Reflux symptoms, anthropometric variables, pancreatic status, meconium ileus, genotype, and chest x ray findings were correlated with pH monitoring data. Results-Five infants (19.2%) had an abnormal fractional reflux time of greater than 10%, seven (26.9%) of 5-10%, and 14 (53.8%) of below 5%. Infants who presented with frequent vomiting had a significantly higher fractional reflux time than infants who had infrequent or no vomiting. There was no significant association between abnormal chest x rays and pathological GOR. Sex, genotype, nutritional status, meconium ileus, and pancreatic enzyme supplementation were not significantly associated with pathological GOR. Conclusions-About one in five newly diagnosed infants with cystic fibrosis had pathological GOR. Pathologically increased reflux was present before radiological lung disease was established. Apart from frequent vomiting, no useful clinical predictors of pathological reflux were found. (Arch Dis Child 1998;78:44-48)

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“…Proposed mechanisms for this association include hyperinflation and diaphragmatic flattening with secondary stretching of the crura, 38 changes in abdominopleural pressure gradients caused by more negative intrathoracic pressure, and increased abdominal pressure from coughing. 39 …”

Section: Aspiration Through the Middlementioning

confidence: 99%