1992
DOI: 10.1111/j.1365-2796.1992.tb00555.x
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Complications of nephropathia epidemica: three cases

Abstract: Haemorrhagic fever with renal syndrome (HFRS) in Scandinavia is called nephropathia epidemica (NE), and is caused by the Puumala-virus, which belongs to the Hanta-virus genus. The clinical course of NE is mostly benign, complications are uncommon, and deaths are rarely observed. We report the cases of three patients who developed serious complications in the course of NE caused by the Puumala-virus. One patient died within 24 h after admission, another developed progressive neuromuscular dysfunction (Guillain-… Show more

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Cited by 50 publications
(31 citation statements)
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“…Previous case reports of severe HFRS have described hypophyseal hemorrhage and panhypopituitarism associated with PUUV and HTNV infections [7][8][9][10][11][35][36][37][38]. The development of hypophyseal hemorrhage and subsequent panhypopituitarism has varied from acute to subacute.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Previous case reports of severe HFRS have described hypophyseal hemorrhage and panhypopituitarism associated with PUUV and HTNV infections [7][8][9][10][11][35][36][37][38]. The development of hypophyseal hemorrhage and subsequent panhypopituitarism has varied from acute to subacute.…”
Section: Discussionmentioning
confidence: 99%
“…There are case reports of hypophyseal hemorrhage and panhypopituitarism in patients with acute NE [7][8][9][10][11]. Postmortem studies of patients with HTNV-induced HFRS, as well as in the few fatal cases of NE, have revealed hemorrhage and necrosis of the pituitary gland in 50-100 % of the autopsies [11][12][13].…”
mentioning
confidence: 99%
“…PUUV infection can occasionally result in a more serious form of the disease characterized by renal failure and circular shock. For NE, there have been reports of fatal outcome (7,18,33), although the mortality rate is less than 2% (20).…”
mentioning
confidence: 99%
“…Der Fall dieses kritisch erkrankten, immunsupprimierten Patienten gibt klinische Hinweise für die potentielle Virulenz der sonst oft asymptomatischen Puumala Infektion. In der Literatur werden ähn-liche Verläufe in einzelnen Fallbeschreibungen aus anderen geographischen Gebieten mit Schock, Nierenversagen und insbesondere zerebraler Beteiligung mit Enzephalopathie und in einem Fall auch gastrointestinaler Symptomatik mit Ileus beschrieben [18,19,20]. Unser Patient bot jedoch die ungewöhnliche Kombination aus HFRS sowie möglichen Symptomen eines HPS bei Puumala-Infektion.…”
Section: Abb 1 Infektionsparameterunclassified