Component composition of body weight in patients with non-alcoholic fatty liver disease

Abstract

The issue of the relationship between the features of the component composition of body weight with the emergence and development of non-alcoholic fatty liver disease (NAFLD) is particularly relevant. The purpose of the study is to determine the features of the component composition of the body weight in patients with NAFLD compared with almost healthy people of the first mature age. A comprehensive examination and analysis of anthropometric data of 112 patients with NAFLD of the first mature age of the Podolski region was carried out in comparison with the anthropometric data of practically healthy people, which were taken from the data bank of the materials of the research center of National Pirogov Memorial Medical University. The necessary anthropometric parameters for determining the absolute amount of adipose tissue, the absolute amount of muscle tissue, the absolute amount of bone component in body weight, using the formulas of J. Matiegka. Statistical analysis of the obtained results was performed in the program “STATISTICA 8” using parametric and non-parametric methods of estimation of the obtained results. It was found that the body fat according to the Matiegka formula in men and women with NAFLD was statistically significantly higher (p<0.001) than in the same sex of healthy men and women. Muscle weight and bone mass calculated by the Matiegka formula in men and women with NAFLD were statistically significantly lower (p<0.05) than in the healthy sex of men and women. Moreover, muscle and bone mass in healthy and NAFLD men were statistically significantly greater (p<0.05) than in the same age groups of women. Men and women with NAFLD have strong inverse correlations between muscle mass and body mass index. Also, the mean strengths of the correlation between the bone mass and body mass index were established. The obtained results, together with a known increase in body fat in NAFLD, show a significant change in muscle and bone mass toward a decrease, which allows us to identify new potential therapeutic targets.