The edaphoclimatic characteristics of the Brazilian Northeast region favor the exploitation of soursop, a crop that is appreciated by the population of the whole country. However, due to the water limitation in this region, it is necessary to study techniques that make saline water feasible in the cultivation of the species. The present study aimed to evaluate phytomass production and quality of soursop cv. 'Morada Nova' seedlings, irrigated with waters of different salinity levels and fertilized with nitrogen (N) doses. The experiment was carried out in a greenhouse at the Center of Sciences and Agri-food Technology of the Federal University of Campina Grande (Pombal-PB), using a randomized block experimental design, in 5 x 4 factorial scheme, which corresponded to five levels of water electrical conductivity-ECw (0.3; 1.1; 1.9; 2.7 and 3.5 dS m-1) and four N doses (70, 100, 130 and 160 mg of N dm-3 of soil), with four replicates and two plants per plot. At 90 days after applying the treatments, the following variables were evaluated to assess the quality of the seedlings: fresh and dry phytomass of stem and leaves, dry phytomass of shoots (aerial parts), roots and total, and Dickson's quality index. Irrigation water with ECw of up to 2.0 dS m-1 allows the production of soursop seedlings, cv. 'Morada Nova', with acceptable reduction of growth. The N dose of 70 mg dm-3 stimulates phytomass production and quality of the seedlings. There was no significant interaction between the factors on the studied variables of seedlings at 90 days after application of the treatments. Water of 2.0 dS m-1 associated with nitrogen fertilization using 70 mg of urea dm-3 of soil should be used in the formation of soursop seedlings.