Components of Achillea filipendulina

Sham’yanov, I. D.; Mallabaev, A.; Sidyakin, G. P.

doi:10.1007/bf00564006

Cited by 5 publications

(6 citation statements)

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“…Araliaceae root and rhizome [47] Achillea filipendulina Asteraceae root [22] Achillea clavennae Asteraceae aerial parts [48] Achillea depressa Asteraceae root [44] Achillea ochroleuca Asteraceae root [49] Anemone tomentosa Ranunculaceae root [50] Angelica dahurica Apiaceae root [51] Anneslea fragrans Theaceae root [25] Apium graveolens Apiaceae whole plant [52] Apocynum venetum Apocynaceae leaves [53] Arabidopsis thaliana Brassicaceae root [54] Artemisia alba Asteraceae aerial parts [20] Artemisia capillaris Asteraceae aerial parts [55] Table 1. Cont.…”

Section: Acantopanax Senticosus (Eleutherococcus Senticosus)mentioning

confidence: 99%

“…Besides, owing to their anti-inflammatory [7], anticoagulant [8], antioxidant [9], anticancer [4,10], hepatoprotective [11], antidiabetic [12], neuroprotective [13], anxiolytic [14], antidepressant [15], antibacterial [16], and cardioprotective [17] effects, researchers have focused their attention on the synthesis of coumarins derivatives in addition to their isolation and purification from natural entities [18]. As one of the most prominent hydroxy coumarins, 7-hydroxy-6,8-dimethoxy coumarin [isofraxidin, IF] along with other related lead compounds (Figure 1), such as 8-hydroxy-6,7-dimethoxycoumarin [ [19][20][21][22][23][24]. In this regard, IF has shown several biological and pharmacological activities including antioxidant [25], cardioprotective [26], weight loss [27], anti-osteoarthritis [28], antimalarial [29], and neuroprotective [30] effects, with promising anticancer and anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

“…As one of the most prominent hydroxy coumarins, 7-hydroxy-6,8-dimethoxy coumarin [isofraxidin, IF] along with other related lead compounds ( Figure 1 ), such as 8-hydroxy-6,7-dimethoxycoumarin [fraxidin], 7, 8-dihydroxy-6-methoxycoumarin [fraxetin], 5, 6-dihydroxy-7-methoxycoumarin [isofraxetin], 6-hydroxy-5, 7-dimethoxycoumarin [fraxinol], and 7-hydroxy-6-methoxycoumarin 8-glucoside [fraxin] are natural-based multi-targets, isolated from several phytomedicines especially in Acantopanax, Achillea, Artemisia, and Fraxinus genera. IF and related compounds attenuate multiple destructive signaling mediators and therapeutic targets in some diseases [ 19 , 20 , 21 , 22 , 23 , 24 ]. In this regard, IF has shown several biological and pharmacological activities including antioxidant [ 25 ], cardioprotective [ 26 ], weight loss [ 27 ], anti-osteoarthritis [ 28 ], antimalarial [ 29 ], and neuroprotective [ 30 ] effects, with promising anticancer and anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

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Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

et al. 2020

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Isofraxidin (7-hydroxy-6, 8-dimethoxy coumarin) (IF) is a hydroxy coumarin with several biological and pharmacological activities. The plant kingdom is of the most prominent sources of IF, which, among them, Eleutherococcus and Fraxinus are the well-known genera in which IF could be isolated/extracted from their species. Considering the complex pathophysiological mechanisms behind some diseases (e.g., cancer, neurodegenerative diseases, and heart diseases), introducing IF as a potent multi-target agent, which possesses several herbal sources and the multiple methods for isolation/purification/synthesis, along with the unique pharmacokinetic profile and low levels of side effects, could be of great importance. Accordingly, a comprehensive review was done without time limitations until February 2020. IF extraction methods include microwave, mechanochemical, and ultrasound, along with other conventional methods in the presence of semi-polar solvents such as ethyl acetate (EtOAc). In addition to the isolation methods, related synthesis protocols of IF is also of great importance. From the synthesis point of view, benzaldehyde derivatives are widely used as precursors for IF synthesis. Along with the methods of isolation and biosynthesis, IF pharmacokinetic studies showed hopeful in vivo results of its rapid absorption after oral uses, leading to different pharmacological effects. In this regard, IF targets varieties of inflammatory mediators including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs). thereby indicating anticancer, cardioprotective, and neuroprotective effects. This is the first review on the synthesis, biosynthesis, isolation, and pharmacokinetic and pharmacological properties of IF in combating different diseases.

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Section: Acantopanax Senticosus (Eleutherococcus Senticosus)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

et al. 2020

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“…The decoction is used in folk medicine as an abortifacient [3] and for gastrointestinal illnesses [4]. The flavonoid [5] and coumarin [6,7] contents have been reported. The component composition of the essential oil of A. filipendulina was studied and found to contain borneol [8], santolina alcohol, filipendulol [4,9], 2-methylhept-2-ene, α-pinene and camphene [10][11][12], and linalool [13].…”

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confidence: 99%

Component composition of essential oils from four species of the genus Achillea growing in Kazakhstan

et al. 2006

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The component composition of the four species Achillea filipendulina, A. sudetica, A. ledebourii, and A. cartilaginea was studied by GC-MS. It was found that the principal components of the essential oil (%) were santolina alcohol (29.1) and borneol (27.9) for A. filipendulina, linalool (11.8) and caryophyllene (8.9) for A. sudetica, germacrene D (20.55) for A. ledebourii, and α-thujone (26.15) and β-thujone (11.76) for A. cartilaginea. The chemical composition of the essential oils from A. sudetica, A. ledebourii, and A. cartilaginea was studied for the first time.

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“…have been studied previously. In addition to umbelliferone derivatives (15) several monoterpenes including santolinatriene are reported (16). A reinvestigation gave germacrene D, phytol, taraxasterol, callitristic acid (17), pimara-8(14),15-dien-19-oic acid (18) and two derivatives of santolinatriene, the epimenc diols 4 and 5.…”

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confidence: 99%