Comportamiento clínico de los tumores cardíacos desde el feto hasta el adulto: serie multicéntrica de 38 pacientes

Abstract

Background: Cardiac tumors are very uncommon at all ages. There are important clinical differences between children and adults in the behavior (Rev Méd Chile 2006; 134: 1135-45).

Regressão tardia espontânea de tumor obstrutivo na valva mitral

“…Thus, complete resolution was observed in 20 out of 24 rhabdomyomas studied in a 20-year follow-up period since the diagnosis made in infants up to 8 months old according to Smythe et al 3 , and in 31 out of 33 cases studied by Bosi et al 2 . Regression is observed up to the age of 5 to 6 years 6,7 . This fact makes the indication of surgical resection of these tumors unnecessary, except in life-threatening situations, as in the case of inflow tract obstruction and, mainly, ventricular outflow tract obstruction 8,9 .…”

“…As such, surgical resection of rhabdomyoma was necessary in only 9 out of 56 of these tumors according to Beghetti ; and in 1 out of 9 cases described by Smythe et al 3 . It has been observed that most of the obstructive rhabdomyomas found in neonates and infants are also subject to regression, and this makes the surgical resection of these tumors necessary only under life-threatening conditions [7][8][9][10] . However, the regression of these tumors is hard to understand, especially in the case of those located in fibrous regions of the heart, as for example in heart valves, as occurred in the unusual case reported here.…”

“…This phenomenon is estimated to occur in 54% to 100% of the cases, even in larger tumors [1][2][3][4][5][6][7] . Thus, complete resolution was observed in 20 out of 24 rhabdomyomas studied in a 20-year follow-up period since the diagnosis made in infants up to 8 months old according to Smythe et al 3 , and in 31 out of 33 cases studied by Bosi et al 2 .…”

“…Less frequently, however, this tumor affects fibrous structures of the heart, with onset later in life, beyond 10 years of age 6,7 . This is why a case of late spontaneous regression of obstructive rhabdomyoma in mitral valve at 14 years of age is worth reporting.…”

“…Among the cardiac tumors, complete and spontaneous regression is observed in rhabdomyomas in 54% to 100% of the cases [1][2][3][4][5][6][7] , even in those causing blood flow obstruction. This phenomenon occurs especially throughout the first year, extending up to 5 years of age 5 .…”