Infants with Down syndrome constitute an ideal population for analysing the development of emotional expression from the rst months of life, due basically to the fact that this chromosomal alteration is identi able from birth and results in well-known dif culties of cognitive development and in basic learning processes. Taking into account the functional aspects of facial expression during initial social interaction, in this review we present a series of studies which, although based on different theoretical approaches and different methodologies, have the common objective of analysing the emotional behaviour of young infants with and without Down syndrome during faceto-face interaction with their mothers. The main conclusions emerging from these studies are: (a) that, as in the case of typically developing infants, Down syndrome infants and their mothers present a series of coordinated and interdependent expressive interchanges; (b) that, despite the differences found between infants with and without Down syndrome in quantitative parameters of expressive behaviour, such as frequency, duration and intensity of the different emotional expressions or their point of initiation in development, what seems to be most signi cant is the clear functional similarity observed in the two groups of subjects during initial mother-infant interaction; and (c) that these differences may be understood by considering different psychobiological explanations as well as the known cognitive de cits.