SummaryIn this paper, an adaptive output feedback dynamic surface control (DSC) strategy is proposed for strict‐feedback stochastic nonlinear systems with input quantization, prescribed performance and dynamic uncertainties. A new quantizer is used to process the input signal, which can avoid the chattering of the quantization signal and keep the upper bound of the quantization error constant. Radial basis functions are used to approximate unknown smooth functions, unmodeled dynamics are processed by dynamic signals, and unmeasurable states are estimated by high gain observer. Hyperbolic tangent functions are employed to handle prescribed performance. The second order command filter is used to replace the first order filter used in general DSC, and the compensation term is added in each step of DSC. By the Lyapunov stability analysis, all signals in the controlled system are semi‐globally uniformly ultimately bounded (SGUUB) in probability. Two examples further prove that the control scheme designed in this paper is reasonable and effective.