Composite clinoptilolite/PCL‐PEG‐PCL scaffolds for bone regeneration: In vitro and in vivo evaluation

Pazarçeviren, Ahmet Engin; Dikmen, Tayfun; Altunbaş, Korhan; Yaprakci, Volkan; Erdemli, Özge; Keskin, Dilek; Tezcaner, Ayşen

doi:10.1002/term.2938

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…Up to date, ceramic‐based scaffolds, 2–6 synthetic thermoplastic polymeric scaffolds, 7–10 or their composites 8,11–13 have widely been employed to satisfy the mechanical characteristics of the native bone tissue. In recent years hydrogels have become a prominent choice of material thanks to their significant intrinsic resemblances to a natural extracellular matrix 14–22 .…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications

et al. 2022

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Bone tissue engineering (BTE) has made significant progress in developing and assessing different types of bio-substitutes. However, scaffolds production through standardized methods, as required for good manufacturing process (GMP), and posttransplant in vivo monitoring still limit their translation into the clinic. 3D printed 5% GelMA scaffolds have been prepared through an optimized and reproducible process in this work. Mesenchymal stem cells (MSC) were encapsulated in the 3D printable GelMA ink, and their biological properties were assessed in vitro to evaluate their potential for cell delivery application. Moreover, in vivo implantation of the pristine 3D printed GelMA has been performed in a rat condyle defect model. Whereas optimal tissue integration was observed via histology, no signs of fibrotic encapsulation or inhibited bone formation were attained. A multimodal imaging workflow based on computed tomography (CT) and magnetic resonance imaging (MRI) allowed the simultaneous monitoring of both new bone formation and scaffold degradation.These outcomes point out the direction to undertake in developing 3D printed-based hydrogels for BTE that can allow a faster transition into clinical use.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications

et al. 2022

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“…CLN improved high quality bone union, cortical growth, and bone-scaffold interaction at the lesion location. These findings demonstrated that CLN in a composite scaffold promotes bone regeneration and aids in bone repair ( Pazarceviren et al, 2017 ; Pazarceviren et al, 2020 ). Recently, CLN was utilized as a food supplement to aid with bone development.…”

Section: Applications Of Zeolites In Bone Tissue Engineeringmentioning

confidence: 87%

“…Linna Zhong et al employed 3D printing extrusion to introduce nanoZIF-8 into polycaprolactone (PCL) and dicalcium phosphate dihydrate (DCPD) composite scaffolds to increase mechanical strength. They may also stimulate osteogenic differentiation of stem cells in vitro without the use of any other osteogenic agent and can steadily improve elastic modulus ( Hao et al, 2019 ; Pazarceviren et al, 2020 ). As shown in Figure 8 , uni-cortical tibial defects treated by scaffolds with zeolite in different concentrations have been compared.…”

Section: Applications Of Zeolites In Bone Tissue Engineeringmentioning

confidence: 99%

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Zeolites: A series of promising biomaterials in bone tissue engineering

Cai

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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As an important worldwide medical issue, bone defect exhibits a variety of physical and psychological consequences on sufferers. Some features of clinical treatments including bone grafting and limb shortening are not satisfactory. Recently, bone tissue engineering has been considered as the most effective approach to dealing with the issue of bone deformities. Meanwhile, a variety of biomaterials have been rationally designed and created for the bone regeneration and tissue repairing. Among all these admirable biomaterials for bone remodeling, zeolite-based materials can serve as efficient scaffold candidates with excellent osteo-inductivity. In addition, the porous nature and high biocompatibility of zeolites endow them with the ability as ideal substrates for cell adhesion and proliferation. More importantly, zeolites are investigated as potential coating materials for implants because they have been proven to increase osteo-conductivity and aid in local elastic modeling. Last but not least, zeolites can also be used to treat bone disorders and act as dietary supplements during the practical applications. Accordingly, numerous benefits of zeolite prompt us to summarize their recent biomedical progress including but not limited to the distinguishing characteristics, broad classifications, as well as promising usages in bone tissue engineering.

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“…In addition, PCL, like many synthetic polymers, is hydrophobic, which limits its polymer-cell interaction [86,87]. Generally, PCL is used as one of the material components [88,89], so minerals such as hydroxyapatite (HA), tetracalcium phosphate (TCP), etc. [90][91][92] are added to the composites to improve the mechanical strength of PCL scaffolds.…”

Section: Poly (ε-Caprolactone)mentioning

confidence: 99%

Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration

et al. 2020

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Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.

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Composite clinoptilolite/PCL‐PEG‐PCL scaffolds for bone regeneration: In vitro and in vivo evaluation

Cited by 8 publications

References 45 publications

In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications

In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications

Zeolites: A series of promising biomaterials in bone tissue engineering

Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration

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