Composite fibrin and collagen scaffold to enhance tissue regeneration and angiogenesis

Yang, Young Il; Seol, Dong Lim; Kim, H.I.; Cho, M.H.; Lee, S.J.

doi:10.1016/j.cap.2006.11.026

Cited by 20 publications

(16 citation statements)

References 7 publications

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“…Respecto al hueso medular desmineralizado bovino, se conoce que es osteoconductivo y permite el transporte de células osteogenéticas desde la pared del seno maxilar hasta las partículas del injerto [47][48][49] . Su uso en forma de Bio-Oss (hueso bovino desproteinizado) ha demostrado mayor neoformación ósea al mezclarlo con PRF 21,22 .…”

Section: Discussionunclassified

Resultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática

Muñoz

Castro-Rodríguez

2019

j.maxilo

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OriginalResultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática *Autor para correspondencia: Correo electrónico: miguelnm8887@gmail.com (Miguel Ángel Núñez Muñoz).Objetivo: El propósito de esta revisión fue evaluar sistemáticamente la literatura científica sobre los resultados que se obtienen al combinar la fibrina rica en plaquetas (PRF) y rellenos óseos en la regeneración ósea guiada. Materiales y métodos:Búsqueda detallada en las bases de datos PubMed, Scopus, Web of Science, ScienceDirect, Cochrane y SciELO para obtener la información más actualizada de los resultados (grado de relleno óseo, éxito de la cirugía, movilidad del implante, complicaciones posquirúrgicas, supervivencia del implante) entre los casos tratados con PRF y los casos donde se combinó PRF con algún tipo de relleno óseo.Resultados: De las 965 publicaciones identificadas inicialmente, se excluyeron reportes clínicos, revisiones, estudios observacionales, etc. Se incluyeron 12 ensayos clínicos que contrastaron las variables entre la técnica con PRF solo y la combinación con un relleno óseo.Conclusión: La combinación entre PRF más rellenos óseos promueve la neoformación ósea, aumenta el trabeculado y mejora los tiempos de cicatrización; sin embargo, al cabo de 6 meses de control los resultados no son diferentes significativamente de los de los grupos que no utilizaron PRF en el procedimiento de levantamiento de piso de seno maxilar con técnica de ventana lateral. Respecto a la preservación de reborde alveolar, los distintos estudios no son concluyentes: algunos indican que la mezcla de PRF con un relleno óseo parece mejorar las proporciones volumétricas; sin embargo, otros refirieron pérdidas óseas en anchura e incluso mayor grado de inflamación.

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Section: Discussionunclassified

Resultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática

Muñoz

Castro-Rodríguez

2019

j.maxilo

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“…To prepare collagen, human collagen Type I (BD Falcon, Germany) was mixed with 0.2-ml neutralization buffer containing 0.15 M NaOH (Klar et al, 2014;Klar et al, 2016). Gelation of mixture fibrin and collagen was started after 5 s and completed between 10 and 30 min at 37 C (Yang, Seol, Kim, Cho, & Lee, 2007).…”

Section: Scaffold Fabricationmentioning

confidence: 99%

Engineered skin graft with stromal vascular fraction cells encapsulated in fibrin–collagen hydrogel: A clinical study for diabetic wound healing

Nilforoushzadeh

Sisakht

Amirkhani

et al. 2020

J Tissue Eng Regen Med

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Despite the abundance of skin substitutes in the worldwide market, major hurdles in developing more complex tissues include the addition of skin appendages and vascular networks as the most important structure. The aim of this research was a clinical feasibility study of a novel prevascularized skin grafts containing the dermal and epidermal layer using the adipose stromal vascular fraction (SVF)‐derived endothelial cell population for vascular network regeneration. Herein, we characterized hydrogel with emphasis on biological compatibility and cell proliferation, migration, and vitality. The therapeutic potential of the prevascularized hydrogel transplanted on five human subjects as an intervention group with diabetic wounds was compared with nonvascularized skin grafts as the control on five patients. Wound planimetric and biometric analysis was performed using a Mann–Whitney nonparametric t‐test (p ≤ .05). The fibrin–collagen hydrogel was suitable for skin organotypic cell culture. There was a significant (p ≤ .05) increased in skin thickness and density in the vascular beds of the hypodermis measured with skin scanner compared with that in the control group. No significant macroscopic differences were observed between the intervention and control groups (p ≤ .05). In summary, we report for the first time the use of autologous dermal–epidermal skin grafts with intrinsic vascular plexus in a clinical feasibility study. The preliminary data showed that SVF‐based full‐thickness skin grafts are safe and accelerate the wound healing process. The next stage of the study is a full‐scale randomized clinical trial for the treatment of patients with chronic wounds.

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“…The addition of other compounds to collagen has been used to prepare collagen‐based mixtures with novel properties. Porous collagen sponges with fibrin were obtained for potential use as a smart template for tissue regeneration . A hybrid composite scaffold composed of poly( d , l ‐lactide‐ co ‐glycolide) and a naturally derived collagen matrix derived from porcine bladder submucosa matrix for use in bone tissue regeneration has been proposed .…”

Section: Collagen Nanocompositesmentioning

confidence: 99%

Biopolymeric nanocomposites for potential biomedical applications

Sionkowska

2016

Polymer International

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This review reports recent advances in the field of biopolymeric composites and nanocomposites for potential biomedical applications. These materials have attracted both academic and, for several composites, industrial attention because they exhibit properties required in the biomedical field. Herein, the structure, preparation and properties of biopolymeric composite blends are discussed in general, and detailed examples are also drawn from the scientific literature and practical work. In this review the most common natural polymers collagen, chitosan and their composites and nanocomposites with inorganic particles are discussed.

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Composite fibrin and collagen scaffold to enhance tissue regeneration and angiogenesis

Cited by 20 publications

References 7 publications

Resultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática

Resultados del uso de la fibrina rica en plaquetas y rellenos óseos en la regeneración ósea guiada. Revisión sistemática

Engineered skin graft with stromal vascular fraction cells encapsulated in fibrin–collagen hydrogel: A clinical study for diabetic wound healing

Biopolymeric nanocomposites for potential biomedical applications

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