Composite Film of Chitosan Loaded Norfloxacin With Improved Flexibility and Antibacterial Activity for Wound Dressing Application

Sebri, Nor Jannah Mohd; Amin, Khairul Anuar Mat

doi:10.13005/ojc/330210

Cited by 22 publications

(4 citation statements)

References 32 publications

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“…The slightly lower values with extracts from IBU-loaded membranes were unexpected, as several reports have shown no cytoxicity of IBU for higher concentrations. 57,58 Overall, this assay demonstrated that the scaffolds were compatible with biomedical applications and no acute toxicity was observed.…”

Section: Resultsmentioning

confidence: 68%

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

et al. 2023

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Section: Resultsmentioning

confidence: 68%

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

et al. 2023

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“…Previous study has also reported the decreased in swelling behaviour after addition of drugs in film due to the higher compactness in film (increased crosslinking by drug) and hindering the water absorption [18]. Nevertheless, all samples could possibly be used as a wound dressing matrix as the film has a high swelling percentage which is more than 900% [19]. Water Vapour Transmission Rate (WVTR).…”

Section: Resultsmentioning

confidence: 99%

Swelling Behaviour and Water Vapour Transmission Rates of Gellan Gum/Collagen Film Containing Gatifloxacin as Dressing Materials

Bakar

Amin

2021

MSF

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In an effort to produce ideal wound dressing, gellan gum/collagen hydrogel films containing different concentrations of gatifloxacin were prepared via evaporative casting method. The films were examined in terms of physical appearances, water uptake and water vapour transmission rate (WVTR). All the films showed good physical appearances. Swelling percentages of the films were decreased, whereas WVTR values were increased as the addition of gatifloxacin was increased. Swelling percentage of gellan gum/collagen film with the lowest percentage of gatifloxacin (GG/C-GAT01) has the highest swelling ratio (2057%). Meanwhile, the WVTR value of GG/C-GAT1 has the highest WVTR value among all films which is 1245 g m-2 day-1. The formulation of GG/C films with the addition of gatifloxacin with good water absorbance and acceptable WVTRs value offered promising materials to be applied as wound dressing materials.

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“…The swelling test, and the swelling response (%) was evaluated using a gravimetric method 39 . Each film sample (2 × 2 cm 2 ) was weighed before and after immersion in 20 ml of phosphate buffer (pH 7).…”

Section: Methodsmentioning

confidence: 99%

Fabrication and evaluation of vitamin doped Zno/AgNPs nanocomposite based wheat gluten films: a promising findings for burn wound treatment

Sajjad,

Ali,

Zia

2023

Sci Rep

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Burn wound treatment remains a significant issue in wound care management especially when multidrug resistant bacterial infection and accumulation are present. Delayed wound healing is mostly due to ineffectiveness of commercially available wound dressings that protects the wound but less efficient in healing perspective. Therefore, nano-based wound dressing might be efficient solution for wound healing management. The present study reports the fabrication and evaluation of zinc oxide (ZnO) or silver nanoparticles (Ag NPs) capped with vitamin A or E nanocomposite that were incorporated in wheat gluten (WG) films. The chemical structure, phase purity, and morphological features confirmed the successful coating of NPs by vitamins A and E and their interaction with WG during film casting. The maximum swelling response was observed by NPs vitamin composite WG films than control films while slow release of vitamins and NPs from films was observed up to 24 h. WG films either carrying ZnO or Ag NPs, and vitamin A or E demonstrated significant antioxidant and antibacterial potential. The NPs-vitamin composite loaded WG films showed wound contraction within 14 days during in vivo burn wound healing experiments on mice model. The rates of wound healing, re-epithelialization, collagen deposition with fibroblast regeneration, adipocytes, and hair follicle development were observed through visual and histopathological examination. The study reveals that vitamin A or E doped ZnO or Ag NPs fabricated in WG can be efficiently used against burn wounds due to their physiochemical and biological properties. Furthermore the biocompatible nature and biodegradable potential make the films more prone to mankind maneuver for initial protection and healing remedy.

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Composite Film of Chitosan Loaded Norfloxacin With Improved Flexibility and Antibacterial Activity for Wound Dressing Application

Cited by 22 publications

References 32 publications

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications

Swelling Behaviour and Water Vapour Transmission Rates of Gellan Gum/Collagen Film Containing Gatifloxacin as Dressing Materials

Fabrication and evaluation of vitamin doped Zno/AgNPs nanocomposite based wheat gluten films: a promising findings for burn wound treatment

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