Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a “Paraganglioma-Like” Paravertebral Case

Cheuk, Wah; Shum, K S; Ng, Wai-Kuen; Chan, John K.

doi:10.1177/1066896920924120

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Less than 100 cases have been reported in the literature [Table 1]. [4,5,8,[11][12][13]15,[18][19][20][21]25,28,31,32,36,39,41,46,[48][49][50][51][52]55,56,58,60,61,69,74,75,77,80,81,87,88,90,91,93,100,102,103] Two patients with primary spinal CHE have been reported. [58,60] e reported median age at diagnosis is 42.5 years, which is nearly identical to our patient's age.…”

Section: Discussionmentioning

confidence: 99%

Dural composite hemangioendothelioma: The first intracranial case

Liu,

Bauer,

Lin

et al. 2024

Surgical Neurology International

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Background: Composite hemangioendothelioma (CHE) is a rare, locally aggressive neoplasm of intermediate malignant potential. It is composed of a mixture of vascular tumors with a predilection for the dermis and subcutis of the extremities. Case Description: In this report, we describe a 41-year-old man who presented with a 2-month history of headache, dizziness, and intermittent seizures. Magnetic resonance imaging showed a hemorrhagic, multilobulated, and dural-based mass with extension into the calvarium. The mass measured 10.3 × 4.8 × 4 cm along the interhemispheric fissure and encased the superior sagittal sinus. Excision was performed, and histopathologic examination revealed a heterogeneous mixture of vascular components consisting of epithelioid hemangioendothelioma, retiform hemangioendothelioma, and hemangioma. This is the first report of a primary intracranial CHE. Conclusion: The spectrum of mesenchymal neoplasms within the cranium expands to encompass CHE.

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Section: Discussionmentioning

confidence: 99%

Dural composite hemangioendothelioma: The first intracranial case

Liu,

Bauer,

Lin

et al. 2024

Surgical Neurology International

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“…In contrast, Mani et al described a case of CHE in the calcaneus, distal femur, proximal tibia, and patella of the left leg, as well as a case of CHE in the left fibula and foot, which were treated with radical resection by above-knee and below-knee amputation, respectively [5]. Cheuk et al encountered a case of CHE in paravertebral soft tissue that was prone to recurrence after resection [19].…”

Section: Et Al Reported Thatmentioning

confidence: 99%

Composite hemangioendothelioma in the cervical spine with kaposiform hemangioendothelioma features in an elderly patient: a case report

et al. 2022

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Background Composite hemangioendothelioma (CHE) is an intermediate group of tumors with features between hemangioma and angiosarcoma both histologically and biologically. CHE is predominant in young and middle-aged adults, but very infrequently affects the spine. We describe the case of primary CHE in the cervical spine exhibiting kaposiform hemangioendothelioma (KHE)-like components that was associated with cervical myelopathy with vertebral body destruction in an elderly woman. We retrospectively reviewed the case of a primary cervical spinal tumor, diagnosed as CHE with KHE-like components in pathological findings, associated with cervical myelopathy and cervical vertebral body destruction. Case presentation An 80-year-old woman presented with progressive cervical myelopathy caused by a cervical spine tumor. Preoperative cervical MRI revealed a neoplastic lesion invading the cervical spine that strongly compressed the spinal cord, causing right upper-limb paralysis. We performed partial tumor resection along with posterior decompression and fixation. Postoperatively, pathological findings showed that the tumor was CHE with KHE-like features. Following radiotherapy, no recurrences have been observed in 21 months. Conclusions This is the first report of CHE with features of KHE in the spine of an elderly patient. Posterior decompression and fusion of the cervical spine and subsequent radiotherapy resulted in a good outcome.

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The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities

Choi

2020

Advances in Anatomic Pathology

281

164

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Soft tissue tumors are a relatively rare and diagnostically challenging group of neoplasms that can have varying lines of differentiation. Accurate diagnosis is important for appropriate treatment and prognostication. In the 8 years since the publication of the 4th Edition of World Health Organization (WHO) classification of soft tissue tumors, significant advances have been made in our understanding of soft tissue tumor molecular biology and diagnostic criteria. The 5th Edition of the 2020 WHO classification of tumors of soft tissue and bone incorporated these changes. Classification of tumors, in general, but particularly in soft tissue tumors, is increasingly based on the molecular characteristics of tumor types. Understanding tumor molecular genetics improves diagnostic accuracy for tumors that have been difficult to classify on the basis of morphology alone, or that have overlapping morphologic features. In many large hospitals in the United States and Europe, molecular tests on soft tissue tumors are a routine part of diagnosis. Therefore, surgical pathologists should be familiar with newly emerging molecular genetic techniques in clinical settings. In the near future, molecular tests, particularly in soft tissue tumor diagnosis, will become as routine during diagnosis as immunohistochemistry is currently. This new edition provides an updated classification scheme and essential diagnostic criteria for soft tissue tumors. Newly recognized entities and subtypes of existing tumor types, several reclassified tumors, and newly defined molecular and genetic data have been incorporated. Herein, we summarize the updates in the WHO 5th Edition, focusing on major changes in each category of soft tissue tumor, and the newly described tumor entities and subtypes.

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Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a “Paraganglioma-Like” Paravertebral Case

Cited by 5 publications

References 13 publications

Dural composite hemangioendothelioma: The first intracranial case

Dural composite hemangioendothelioma: The first intracranial case

Composite hemangioendothelioma in the cervical spine with kaposiform hemangioendothelioma features in an elderly patient: a case report

The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities

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