Composite materials based on hydroxyapatite embedded in biopolymer matrices: ways of synthesis and application

Yanovska, Anna; Bolshanina, S.

doi:10.1016/b978-0-12-816901-8.00013-4

Cited by 4 publications

(8 citation statements)

References 146 publications

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“…Biopolymer composites for medical applications should have similarities to the complex architecture of the human body and polymer composites. Furthermore, biopolymer-based drug and bioactive agent release systems should be developed as multifunctional release systems for maintaining the functionality of biological molecules [ 37 , 38 ]. There are around 28 types of collagen, but the most prevalent type found in the ECM of tendon and bone tissues is type I collagen [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite is deposited into the holes of type I collagen in the process of bone biomineralization [ 40 ]. Therefore, due to their compositional and structural analogies to natural bones, the composites of collagen and HA are of special interest among all kinds of bone substitutes [ 38 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

“…Osteoblast-secreted ECM may initially be amorphous and noncrystalline but gradually transform into more crystalline forms [ 43 ]. One of the main challenges to bone tissue engineering is to develop scaffolds with optimal mechanical properties, biodegradability, and appropriate architecture for cell colonization and organization, which can ensure the integration of a scaffold with host tissue [ 38 , 41 ]. It should be clarified that natural bone is a kind of nanocomposite material that is heterogeneous and anisotropic.…”

Section: Introductionmentioning

confidence: 99%

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Synthetic Calcium–Phosphate Materials for Bone Grafting

Mishchenko,

Yanovska,

Kosinov

et al. 2023

Polymers

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Synthetic bone grafting materials play a significant role in various medical applications involving bone regeneration and repair. Their ability to mimic the properties of natural bone and promote the healing process has contributed to their growing relevance. While calcium–phosphates and their composites with various polymers and biopolymers are widely used in clinical and experimental research, the diverse range of available polymer-based materials poses challenges in selecting the most suitable grafts for successful bone repair. This review aims to address the fundamental issues of bone biology and regeneration while providing a clear perspective on the principles guiding the development of synthetic materials. In this study, we delve into the basic principles underlying the creation of synthetic bone composites and explore the mechanisms of formation for biologically important complexes and structures associated with the various constituent parts of these materials. Additionally, we offer comprehensive information on the application of biologically active substances to enhance the properties and bioactivity of synthetic bone grafting materials. By presenting these insights, our review enables a deeper understanding of the regeneration processes facilitated by the application of synthetic bone composites.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthetic Calcium–Phosphate Materials for Bone Grafting

Mishchenko,

Yanovska,

Kosinov

et al. 2023

Polymers

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“…Many articles have reported that sodium alginate forms porous, strong, and stable solid gels via ionically cross-linking with calcium [40,[56][57][58][59]. Although the cross-linked alginate-ion gel is known as a biocompatible and bioactive network with unique cell adhesion properties, it has disadvantages, such as limited durability in physiological conditions, which affects the swelling behavior and release of the drug [44][45][46]59,60]. The prepared composite gel was loaded with LOH, an extract employed in diverse medicine for its biologically active compounds [36,37,61,62].…”

Section: Discussionmentioning

confidence: 99%

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

et al. 2021

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In the current paper, we fabricated, characterized, and applied nanocomposite hydrogel based on alginate (Alg) and nano-hydroxyapatite (nHA) loaded with phenolic purified extracts from the aerial part of Linum usitatissimum (LOH) as the bone tissue engineering scaffold. nHA was synthesized based on the wet chemical technique/precipitation reaction and incorporated into Alg hydrogel as the filler via physical cross-linking. The characterizations (SEM, DLS, and Zeta potential) revealed that the synthesized nHA possess a plate-like shape with nanometric dimensions. The fabricated nanocomposite has a porous architecture with interconnected pores. The average pore size was in the range of 100–200 µm and the porosity range of 80–90%. The LOH release measurement showed that about 90% of the loaded drug was released within 12 h followed by a sustained release over 48 h. The in vitro assessments showed that the nanocomposite possesses significant antioxidant activity promoting bone regeneration. The hemolysis induction measurement showed that the nanocomposites were hemocompatible with negligible hemolysis induction. The cell viability/proliferation confirmed the biocompatibility of the nanocomposites, which induced proliferative effects in a dose-dependent manner. This study revealed the fabricated nanocomposites are bioactive and osteoactive applicable for bone tissue engineering applications.

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“…Among the various biopolymers, gelation-based HAP composites have received wide attention for the bone repair process, thanks to their structural similarity with collagen, the main organic constituent of the natural bone. Also, excellent biodegradability, biocompatibility, and low antigenicity behavior made the gelation the ideal organic constituent for HAP coating in impaired bones as it can offset the mechanical limitations such as low fracture stiffness and fragility of the pure HAP [3].…”

Section: Introductionmentioning

confidence: 99%

Thermal Degradation Process and Kinetics of Gelatin/HAP Composites

Purushotham¹

2022

ECS Trans.

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Hydroxyapatite (HAP)-loaded gelatin, a biopolymeric composite, has gained a lot of attention in biomedical applications like bone regeneration because it compensates for the low fracture stiffness and fragility of pure HAP. Furthermore, it improves bone injury tolerance by controlling the amorphous calcium phosphate deposition kinetics and microstructure. Doping metal ions in HAP and thereafter preparing gelatin/HAP composites may result in an increase in the desired property upgrades. Understanding the breakdown kinetics of gelatin/HAP composites offers the opportunity for the composites to be engineered for specific purposes. In the present work, gelatin/HAP composites with/without metal-ion doping were prepared and subjected to thermal degradation studies using thermogravimetric analysis under a nitrogen environment to understand their degradation kinetics.

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Composite materials based on hydroxyapatite embedded in biopolymer matrices: ways of synthesis and application

Cited by 4 publications

References 146 publications

Synthetic Calcium–Phosphate Materials for Bone Grafting

Synthetic Calcium–Phosphate Materials for Bone Grafting

Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold

Thermal Degradation Process and Kinetics of Gelatin/HAP Composites

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