Composite nanoclay-hydroxyapatite-polymer fiber scaffolds for bone tissue engineering manufactured using pressurized gyration

Kundu, Krishna; Afshar, Ayda; Katti, Dinesh R.; Edirisinghe, Mohan; Katti, Kalpana S.

doi:10.1016/j.compscitech.2020.108598

Cited by 57 publications

(25 citation statements)

References 79 publications

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“…The addition of montmorillonite combined with hydroxyapatite resulted in an increase in cell viability and proliferation. Moreover, the osteogenic differentiation of MSCs increased in presence of the scaffold loaded with the clay mineral [22]. Kazemi-Aghdam and co-workers developed an injectable chitosanmodified halloysite nanotubes hydrogel with enhanced mechanical strength and improved osteoinductivity for bone tissue engineering.…”

Section: Orthopaedic Applicationsmentioning

confidence: 99%

Inorganic Nanomaterials in Tissue Engineering

et al. 2022

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In recent decades, the demand for replacement of damaged or broken tissues has increased; this poses the attention on problems related to low donor availability. For this reason, researchers focused their attention on the field of tissue engineering, which allows the development of scaffolds able to mimic the tissues’ extracellular matrix. However, tissue replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology as well as adequate mechanical, chemical, and physical properties to stand the stresses and enhance the new tissue formation. For this purpose, the use of inorganic materials as fillers for the scaffolds has gained great interest in tissue engineering applications, due to their wide range of physicochemical properties as well as their capability to induce biological responses. However, some issues still need to be faced to improve their efficacy. This review focuses on the description of the most effective inorganic nanomaterials (clays, nano-based nanomaterials, metal oxides, metallic nanoparticles) used in tissue engineering and their properties. Particular attention has been devoted to their combination with scaffolds in a wide range of applications. In particular, skin, orthopaedic, and neural tissue engineering have been considered.

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Section: Orthopaedic Applicationsmentioning

confidence: 99%

Inorganic Nanomaterials in Tissue Engineering

et al. 2022

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“…The results showed that the in vitro proliferation and osteogenic differentiation of human adipose stem cells (hASCs) were improved. Kundu et al [129] found that the addition of MMT significantly increased the alkaline phosphatase (ALP) expression of mesenchymal stem cells (MSCs). Kim et al [130] studied the effect and mechanism of nano-MMT on the differentiation of osteoblasts and osteoclasts in vivo and in vitro.…”

Section: Cation Exchange Modificationmentioning

confidence: 99%

Progress in Montmorillonite Functionalized Artificial Bone Scaffolds: Intercalation and Interlocking, Nanoenhancement, and Controlled Drug Release

Dong-ying

Пин

et al. 2022

Journal of Nanomaterials

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Montmorillonite (MMT) has attracted widespread attention in the field of bone tissue engineering in recent years because of its interlayer domain structure. The progress of MMT application was reviewed in this article. Concretely, the application of MMT was mainly explained from the structural characteristics, mechanical strengthening mechanism, organic functionalization, and drug loading and release. Firstly, the polar polymer molecular chains are easily induced into the interlayer domain of MMT to form an interlock and achieve the mechanical strengthening of scaffold. Secondly, the “sandwich” sheet structure of MMT can be exfoliated into graphene-like MMT nanosheets, providing a nanostrengthening effect for polymer matrix. In addition, MMT’s interlayer domain provides a favorable environment for the loading and slow release of drugs, and it is an ideal platform for the functionalization of bone scaffolds. More importantly, MMT can be easily modified by cation exchange and chemical reaction to further improve the compatibility of composites: such as strengthening mechanical interlocking and nanostrengthening effects and achieving controllable loading and release of drugs. It is expected to provide a reference for improving the application of bone tissue engineering scaffolds.

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“…In addition, incorporation of HAP nanoparticles showed a sufficient increase in alkaline phosphatase (ALP) secretion and promoted mineral deposition. In order to fully imitate bone ECM’s composition, the studies [ 72 , 73 , 74 , 75 ] presented the electrospun nanocomposite materials based on collagen and HAP. Vozzi et al [ 76 ] investigated the impact of HAP content (10, 20, and 30%) and genipin crosslinking on biological features of collagen/gelatin/genipin/HAP fibrous scaffolds.…”

Section: Modern Polymer-based Fibrous Compositesmentioning

confidence: 99%

Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering

2021

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Currently, the significantly developing fields of tissue engineering related to the fabrication of polymer-based materials that possess microenvironments suitable to provide cell attachment and promote cell differentiation and proliferation involve various materials and approaches. Biomimicking approach in tissue engineering is aimed at the development of a highly biocompatible and bioactive material that would most accurately imitate the structural features of the native extracellular matrix consisting of specially arranged fibrous constructions. For this reason, the present research is devoted to the discussion of promising fibrous materials for bone tissue regeneration obtained by electrospinning techniques. In this brief review, we focus on the recently presented natural and synthetic polymers, as well as their combinations with each other and with bioactive inorganic incorporations in order to form composite electrospun scaffolds. The application of several electrospinning techniques in relation to a number of polymers is touched upon. Additionally, the efficiency of nanofibrous composite materials intended for use in bone tissue engineering is discussed based on biological activity and physiochemical characteristics.

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Composite nanoclay-hydroxyapatite-polymer fiber scaffolds for bone tissue engineering manufactured using pressurized gyration

Cited by 57 publications

References 79 publications

Inorganic Nanomaterials in Tissue Engineering

Inorganic Nanomaterials in Tissue Engineering

Progress in Montmorillonite Functionalized Artificial Bone Scaffolds: Intercalation and Interlocking, Nanoenhancement, and Controlled Drug Release

Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering

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