Composite scaffolds based on calcium phosphates and barium titanate obtained through bacterial cellulose templated synthesis

Draghici, Alina‐Denisa; Busuioc, Cristina; Mocanu, Alexandra; Nicoară, Adrian-Ionuţ; Iordache, Florin; Jinga, Sorin‐Ion

doi:10.1016/j.msec.2020.110704

Cited by 11 publications

(12 citation statements)

References 45 publications

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“…Another noteworthy approach to improve scaffold biomechanical properties rely on the addition of metal traces such as strontium, which is naturally found in bone ECM [ 35 , 36 ] or non-naturals such us barium titanate [ 37 , 38 ]. Either one in combination with CaP composites seems to produce a good response regarding not only cellular adherence and proliferation, but promoting osteogenic differentiation.…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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“…Recently various materials have been utilized in the field of hard tissue engineering [10][11][12], e.g. hydroxyapatite (HAp) [13], bioactive glasses, bio-ceramics [14], bio-scaffolds [15,16], etc.…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

Sharifianjazi

Pakseresht

Asl

et al. 2020

jcc

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“…It was observed that certain changes associated with endothermic processes occurred in the thermogravimetric (TG) curve with the addition of silver nanoparticles. Hence, in the 450-600 • C interval, exothermic effects generated by the combustion of BC were observed (see Figure 4a), while in the 600-700 • C interval, it can be assumed that the oxidation of silver nanoparticles and dehydroxylation of HAp occurred [15]. In order to demonstrate the composition, hydroxyapatite was analyzed by XRD technique.…”

Section: Resultsmentioning

confidence: 99%

“…Many studies [14][15][16][17] have shown that BC could provide tissue regeneration and substitution, thus being used for bioengineering of hard, cartilaginous, and soft tissues. Bacterial cellulose is widely used as a wound dressing material, and nanomaterials obtained from BC show great antimicrobial properties [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

In Situ and Ex Situ Designed Hydroxyapatite: Bacterial Cellulose Materials with Biomedical Applications

et al. 2020

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Hydroxyapatite (HAp) and bacterial cellulose (BC) composite materials represent a promising approach for tissue engineering due to their excellent biocompatibility and bioactivity. This paper presents the synthesis and characterization of two types of materials based on HAp and BC, with antibacterial properties provided by silver nanoparticles (AgNPs). The composite materials were obtained following two routes: (1) HAp was obtained in situ directly in the BC matrix containing different amounts of AgNPs by the coprecipitation method, and (2) HAp was first obtained separately using the coprecipitation method, then combined with BC containing different amounts of AgNPs by ultrasound exposure. The obtained materials were characterized by means of XRD, SEM, and FT-IR, while their antimicrobial effect was evaluated against Gram-negative bacteria (Escherichia coli), Gram-positive bacteria (Staphylococcus aureus), and yeast (Candida albicans). The results demonstrated that the obtained composite materials were characterized by a homogenous porous structure and high water absorption capacity (more than 1000% w/w). These materials also possessed low degradation rates (<5% in simulated body fluid (SBF) at 37 °C) and considerable antimicrobial effect due to silver nanoparticles (10–70 nm) embedded in the polymer matrix. These properties could be finetuned by adjusting the content of AgNPs and the synthesis route. The samples prepared using the in situ route had a wider porosity range and better homogeneity.

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Composite scaffolds based on calcium phosphates and barium titanate obtained through bacterial cellulose templated synthesis

Cited by 11 publications

References 45 publications

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

In Situ and Ex Situ Designed Hydroxyapatite: Bacterial Cellulose Materials with Biomedical Applications

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