Composites and Nanocomposites Based on Polylactic Acid

Corobea, Mihai Cosmin; Vuluga, Zina; Florea, Dorel; Miculescu, Florin; Voicu, Ştefan Ioan

doi:10.1002/9781119441632.ch160

Cited by 2 publications

(1 citation statement)

References 116 publications

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“…SVPs were washed with acetone and dried in an oven at 90–100 °C for 24 h. Then dried SVPs (20 wt.%) were mixed with PLA (80 wt.%) (Goodfellow, 459-898-81, Coraopolis, PA, USA) in a mechanical mixer operating at 150 °C for 25 min at a rotor speed of 50–60 rpm [ 29 ]. After mixing, the composites were poured into a Teflon mold and pressed into thin plates with a custom hot press operating at 150 °C and 10–12 MPa for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation

et al. 2021

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Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs’ adhesion and proliferation.

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Section: Methodsmentioning

confidence: 99%