Composites of amorphous calcium phosphate and poly(hydroxybutyrate) and poly(hydroxybutyrate-co-hydroxyvalerate) for bone substitution: assessment of the biocompatibility

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…Similarly, biocomposites of PHBHV with both HA and amorphous carbonated apatite (almost ACP) appeared to have promising potential for repair and replacement of damaged bones. [416][417][418][419] Along these lines, PCL is used as a slowly biodegradable but good biocompatible polymer. PCL/HA and PCL/CDHA biocomposites have already been discussed as suitable materials for substitution, regeneration and repair of bone tissues.…”

“…Various ACP-based biocomposites and hybrid formulations for dental applications have been developed, [508][509][510][511] and several ACP-based formulations have been investigated as potential biocomposites for bone grafting 419,[512][513][514] and drug delivery. 515 ACP/ PPF biocomposites were prepared by in situ precipitation, 513 while PHB/carbonated ACP and PHBHV/carbonated ACP biocomposites appeared to be well-suited as slowly biodegradable bone substitution materials.…”

“…515 ACP/ PPF biocomposites were prepared by in situ precipitation, 513 while PHB/carbonated ACP and PHBHV/carbonated ACP biocomposites appeared to be well-suited as slowly biodegradable bone substitution materials. 419 Another example is hybrid nanodimensional capsules, ~50-70 nm in diameter, which were fabricated by ACP mineralization of shell cross-linked polymer micelles and nano-sized cages. 514 These nano-sized capsules consisted of remove the device after healing occurred.…”

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…Both bioactivity and mechanical properties of these biocomposites can be tailored by varying the volume percentage of calcium orthophosphates. Similarly, biocomposites of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) with both HA and amorphous carbonated apatite (almost ACP) appeared to have a promising potential for repair and replacement of damaged bones [346][347][348][349].…”

“…Besides, several ACPbased formulations were investigated as potential biocomposites for bone grafting [349,[419][420][421]. Namely, ACP/PPF biocomposites were prepared by in situ precipitation [420], while PHB/carbonated ACP and PHBHV/ carbonated ACP biocomposites appeared to be well suited as slowly biodegradable bone substitution material [349].…”