Composition and biological activities of essential oils from four Heracleum species

Firuzi, Omidreza; Asadollahi, Mojtaba; Gholami, Maryam; Javidnia, Katayoun

doi:10.1016/j.foodchem.2010.02.026

Cited by 104 publications

(109 citation statements)

References 23 publications

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“…This leads to the assumption that the combination of different antioxidants might have a synergistic effect, a point that has been made previously in the case of stroke [225] and trauma-induced hearing loss [255] and supports the idea of using plant derived products, which contain a multitude of different molecules, as sources of antioxidants [256,257].…”

Section: Future Directionssupporting

confidence: 64%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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Section: Future Directionssupporting

confidence: 64%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

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“…Cell viability following exposure to plant extracts or isolated compounds were measured by the MTT method as follows (Mosmann 1983;Firuzi et al 2010): Suspensions of LS180, MCF-7 and MOLT-4 cells (100 ml) were plated in 96-well microplates at a density of 50 000 cells/mL. After overnight incubation, 3-4 different concentrations of the extracts or pure compounds were added to the wells in duplicate.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Jassbi

Firuzi

Miri

et al. 2016

Pharmaceutical Biology

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Context The genus Anthemis L. (Asteraceae) comprises about 195 species which are widely used in the pharmaceutical, cosmetic and food industries. Objective Anthemis mirheydari Iranshar, an endemic plant from Iran, was investigated for its cytotoxic properties and chemical constituents. Materials and methods The whole parts of the plant (320 g) were extracted by dichloromethane and methanol for four days, successively. The cytotoxic activity of both dichloromethane and methanol extracts were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric methods against three human cancer cell lines including LS180, MCF-7 and MOLT-4. Different concentrations (10-100 mg/mL) of the plant extracts were tested to obtain IC 50 values. The dichloromethane extract of A. mirheydari was subjected to silica gel-column and thin layer chromatography for purification of its chemical constituents and the isolated compounds were further tested against MOLT-4 cells. The structures of the pure compounds were elucidated using different spectral data including nuclear magnetic resonance and electron impact mass spectra. Results The IC 50 values of the dichloromethane extract were 30.8 ± 6.7, 25.2 ± 6.5 and 8.6 ± 1.1 mg/mL (means ± standard error) for the above-mentioned cell lines, respectively. Two triterpenoids, taraxasterol (1) and pseudotaraxasterol (2), one sterol, b-sitosterol (3) and one coumarin, 7-methoxycoumarin (4) were isolated from the extract. The IC 50 of the mixture of compounds 1 and 2 as well as compounds 3 and 4 were higher (4100 mM) than that reported for the dichloromethane extract against MOLT-4 cells. Conclusion The dichloromethane extract was the most active one among the tested material.ARTICLE HISTORY

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“…[14][15][16] Essential oil compounds of the genus were also studied. [17][18][19] Although the phytochemical studies and bioactivity studies are mostly conducted with the coumarin compounds of the genus, we would like to examine the flavonoid content of H. pastinaca Fenzl. (Figure 1) which is a rare endemic tiny plant, mainly distributed in the inner and the southwest region of Anatolia.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%